Suppression of T cell immunity and antibody production during virus infection and sepsis

病毒感染和败血症期间 T 细胞免疫和抗体产生的抑制

• 批准号: 2748405
• 金额: --
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2748405
• 关键词: Suppression; cell; immunity; antibody; production

The generation of protective antibodies against infection is dependent on "help" from CD4+ T follicular helper (TFH) cells which are elicited inresponse to bacteria and viruses, such as influenza and SARS CoV-2. However, these cells can decline when immune responses are over-exaggerated (sepsis). The student will use immunological techniques and innovative gene profiling strategies to examine why low numbers ofCD4+ TFH cells correlate with poor outcome in sepsis

抗感染保护性抗体的产生依赖于CD 4 + T滤泡辅助细胞（TFH）的“帮助”，TFH细胞是对细菌和病毒（如流感和SARS CoV-2）的反应。然而，当免疫反应过度时（败血症），这些细胞可能会下降。学生将使用免疫学技术和创新的基因分析策略来研究为什么低数量的CD 4 + TFH细胞与脓毒症的不良结局相关