Bacteriophages as key players in bacterial adaptation to the human gut

噬菌体是细菌适应人类肠道的关键参与者

• 批准号: 2748665
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2748665
• 关键词: Bacteriophages; key; players; bacterial; adaptation

Bacteriophages are the most abundant biological entity on the planet, but their role in the human gut microbiome is poorly understood. In this project, the student will investigate how bacteriophages contribute to the adaptation of commensal bacteria to the human gut. Is bacteriophage infection detrimental or beneficial to successful colonisation of the gut? What is the function of prophages, i.e. phages that integrate into the bacterial genome? Findings from this work will help develop phage-based strategies for modulation of the gut microbiome for the benefit of human health. The project will combine bioinformatics approaches with laboratory experiments to determine the role of bacteriophages in the gut microbiome.

噬菌体是地球上最丰富的生物实体，但它们在人类肠道微生物组中的作用却知之甚少。在这个项目中，学生将研究噬菌体如何有助于肠道细菌适应人类肠道。噬菌体感染对肠道的成功定植是有害还是有益？整合到细菌基因组中的前噬菌体即噬菌体的功能是什么？这项工作的发现将有助于开发基于噬菌体的策略，用于调节肠道微生物组，以造福人类健康。该项目将联合收割机生物信息学方法与实验室实验相结合，以确定噬菌体在肠道微生物组中的作用。