Advanced multiparametric MRI for the characterisation of soft tissue sarcoma and response to neoadjuvant therapy

点击翻译按钮获取中文摘要

Imaging technology is required to enable personalised adaptation of treatment for improved outcomes for patientswith soft-tissue sarcoma, specifically techniques which can identify those patients who would benefit fromneoadjuvant therapy prior to surgery, accurately assess tumour response, and enable expedient switching to a moreefficacious agent/treatment regime as necessary. The objective of this project is to use advanced, clinicallytranslatable multi-parametric MRI strategies, coupled with computational pathology, to define imaging biomarkersassociated with the heterogeneous phenotype that develops within patient-derived xenograft models of soft-tissuesarcoma, and for the assessment of tumour response to neoadjuvant therapy.