Analysing the differentiation and function of the neurons damaged in Huntington's Disease

分析亨廷顿病中受损神经元的分化和功能

• 批准号: 2750382
• 金额: --
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2750382
• 关键词: Analysing; differentiation; function; neurons; damaged

Striatal medium spiny neurons (MSNs) bear the brunt of pathology in Huntington's disease (HD).You will use a range of in vitro and in vivo cell,molecular genetic and whole animal techniques todissect how the transcription factors FoxP1 andMef2C function in MSNs differentiation. Thisknowledge is key for optimising MSN differentiationprotocols from stem cells for disease modelling andcell therapies, and understanding the degenerationof MSNs in HD.

纹状体中型棘状神经元（MSNs）在亨廷顿病（HD）中首当其冲。您将使用一系列体外和体内细胞，分子遗传学和整体动物技术来剖析转录因子FoxP1和Mef2C在MSNs分化中的功能。这些知识是优化MSN分化方案的关键，用于疾病建模和细胞治疗，并了解HD中MSN的变性。