High Resolution PET Detectors for Combined PET-MR Small Animal Imaging

用于组合 PET-MR 小动物成像的高分辨率 PET 探测器

• 批准号: 7106126
• 负责人: KANAI SHAH
• 金额: $ 10万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-03 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106126
• 关键词: brain mapping; data collection; disasters; face; lead; magnetic field; magnetic resonance imaging; performance; positron emission tomography; radiotracer; reading; sensory receptors; tissues

DESCRIPTION (provided by applicant): The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the use of targeted radiolabeled probes. Unfortunately, precise signal localization can be extremely difficult due to low spatial resolution and the lack of anatomical information. Magnetic Resonance Imaging (MRI) can provide high spatial resolution and excellent soft tissue contrast, but suffers from poor signal strength leading to low sensitivity. The overall goal of the proposed effort is to combine the best features of PET and MR modalities for small animal studies into a single imaging instrument that will record data in both imaging modalities near simultaneously. The most immediate benefit of the melded system will be to provide high-resolution anatomical context for muPET studies. This will lead to better overall understanding of the origin of the PET signals. The 'in-register' MR images will be used to compute scatter and attenuation in the muPET images and also to estimate partial volume errors in the lower-resolution PET scans, thus aiding quantification of the PET signal. The melded system will open up a number of opportunities not possible with current independent technologies. For example, combined fMRI and muPET neuroreceptor brain mapping studies in small animals would be possible. The goal of the proposed Phase I project is to investigate PET detector design that is adequate for integration with an MR system for combined PET-MR imaging.

描述（由申请人提供）：理想的生物成像系统将提供生命系统的非侵入性、高分辨率、高灵敏度、三维（3D）图像。正电子发射断层扫描（PET）通过使用靶向放射性标记探针对一系列生物过程提供高灵敏度。不幸的是，由于空间分辨率低和缺乏解剖信息，精确的信号定位可能非常困难。磁共振成像（MRI）可以提供高的空间分辨率和优异的软组织对比度，但是遭受导致低灵敏度的差的信号强度。所提出的努力的总体目标是将用于小动物研究的PET和MR模态的最佳特征联合收割机结合到单个成像仪器中，该成像仪器将几乎同时记录两种成像模态中的数据。融合系统最直接的好处是为muPET研究提供高分辨率的解剖背景。这将导致更好地全面了解PET信号的起源。“配准”MR图像将用于计算muPET图像中的散射和衰减，还用于估计较低分辨率PET扫描中的部分体积误差，从而帮助PET信号的量化。融合系统将开辟许多当前独立技术无法实现的机会。例如，在小动物中进行功能磁共振成像和muPET神经受体脑映射研究将是可能的。拟议的I期项目的目标是研究PET探测器设计，该设计足以与MR系统集成，用于组合PET-MR成像。