Myocardial Perfusion Quantitation with Dual Spectra Echo

双光谱回波心肌灌注定量

• 批准号: 7318322
• 负责人: MAREK BELOHLAVEK
• 金额: $ 32.47万
• 依托单位: MAYO CLINIC ARIZONA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7318322
• 关键词: angiocardioultrasonography; artery stenosis; blood flow measurement; cardiovascular imaging /visualization; coronary artery; densitometry; dogs; echocardiography; mathematical model; method development; model design /development; myocardial ischemia /hypoxia; myocardium; perfusion; ultrasound blood flow measurement

DESCRIPTION (provided by applicant): Quantitation of local myocardial perfusion is essential for the assessment of the extent of myocardial ischemia. The existing noninvasive approaches in myocardial contrast echocardiography (MCE) are significantly hampered by limited reproducibility due to variable attenuation of the harmonic signals emanating from insonated contrast microbubbles. Our long-term objective is to study nonlinear ultrasound signal propagation within the cardiovascular system and develop a robust mathematical model for attenuation compensation. Our preliminary method for decomposing a received broadband signal into the fundamental and harmonic (ie, dual) frequency spectra has resulted in the introduction of a Harmonic-to- Fundamental Ratio peak (HFRp) of the spectral envelope. The HFRp parameter self-compensates for variations in signal attenuation while differentiating perfused and nonperfused myocardium. We hypothesize that an analytical model of linear and nonlinear ultrasound signal propagation can reproducibly correct for harmonic spectrum attenuation. The short-term objective of the present reseach is to test the hypothesis in calibrated tissue phantoms and animal models of myocardial perfusion under defined levels of signal attenuation. Aim 1: Characterize changes in the fundamental and harmonic spectra during propagation through a tissue phantom with calibrated attenuation. Aim 2: Define the precision and accuracy of variable flow velocity measurements in vivo using attenuation correction by the proposed dual spectrum method. Aim 3: Determine the precision and accuracy of the dual spectrum method for estimation of regional myocardial blood flow under varying levels of attenuation. Aim 4: Validate the new method for quantitation of myocardial perfusion during coronary stenosis. Aim 5: Validate the dual spectrum method for perfusion quantitation in microvascular obstruction. To accomplish these aims, we will analyze digital radiofrequency ultrasound data obtained from tissue perfusion phantoms and beating dog hearts with induced ischemia, determine the region of ischemic risk in stained specimens, and define the reference perfusion flow from local activities of radiolabeled microspheres. The novelty is in the use of the fundamental component of the dual spectra as an immediate "internal reference" for automatic attenuation compensation of the harmonic "perfusion imaging" component. Such a principle should allow reproducible quantitation of perfusion by MCE.

描述（由申请人提供）：

项目成果

Impact of acute moderate elevation in left ventricular afterload on diastolic transmitral flow efficiency: analysis by vortex formation time.

• DOI: 10.1016/j.echo.2008.12.006
• 发表时间: 2009-04
• 期刊: JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
• 影响因子: 6.5
• 作者: Jiamsripong, Panupong;Calleja, Anna M.;Alharthi, Mohsen S.;Dzsinich, Mate;McMahon, Eileen M.;Heys, Jeffrey J.;Milano, Michele;Sengupta, Partho P.;Khandheria, Bijoy K.;Belohlavek, Marek
• 通讯作者: Belohlavek, Marek

Parametric harmonic-to-fundamental ratio contrast echocardiography: a novel approach to identification and accurate measurement of left ventricular area under variable levels of ultrasound signal attenuation.

参数谐波与基波比对比超声心动图：一种在不同水平的超声信号衰减下识别和准确测量左心室面积的新方法。

• DOI: 10.1016/j.ultras.2006.12.002
• 发表时间: 2007
• 期刊: Ultrasonics
• 影响因子: 4.2
• 作者: Yoshifuku,Shiro;Chen,Shigao;McMahon,EileenM;Yoshikawa,Akiko;Sengupta,ParthoP;Korinek,Josef;Belohlavek,Marek
• 通讯作者: Belohlavek,Marek

Analysis of postsystolic myocardial thickening work in selective myocardial layers during progressive myocardial ischemia.

进行性心肌缺血期间选择性心肌层收缩后心肌增厚的分析。

• DOI: 10.1016/j.echo.2006.04.023
• 发表时间: 2006
• 期刊: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
• 作者: Wang,Jianwen;Urheim,Stig;Korinek,Josef;Abraham,TheodoreP;McMahon,EileenM;Belohlavek,Marek
• 通讯作者: Belohlavek,Marek