Ultrasonic microbubbles as a therapy for biofilm targeting in bone repair

超声波微泡作为骨修复中生物膜靶向的治疗方法

• 批准号: 2750772
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2750772
• 关键词: Ultrasonic; microbubbles; therapy; biofilm; targeting

In this PhD studentship, we wish to determine whether ultrasound-responsive microbubbles stimulate biofilm dispersal in bone infections. Infections are one of the primary reasons why bone implants fail, and is a major source of morbidity in acute traumatic bone fracture. Microbubbles, which can be injected into the circulation and which can be stimulated remotely using ultrasound energy, offer an opportunity for targeting infected bone noninvasively. The project will help us understand and determine the ultrasound parameters necessary for biofilm dispersal and antibiotic delivery. In parallel we wish to determine the parameters that stimulation tissue penetration of candidate antibiotics. in organotypic models of bone tissue. The project will lead to the training of a PhD student in a vibrant, competitive group in an interdisciplinary area of emerging engineering research with a direct clinical translation focus. It will enable to us to determine the design parameters for a novel device/technology for deployment in the military. It will also integrate closely with our clinically-focussed aims and will cement a partnership for future studies.

在这个博士生项目中，我们希望确定超声响应微泡是否刺激骨感染中的生物膜分散。感染是骨植入物失败的主要原因之一，也是急性创伤性骨折发病率的主要来源。微泡可以被注射到血液循环中，并且可以使用超声能量远程刺激，这为非侵入性地靶向感染的骨提供了机会。该项目将帮助我们了解和确定生物膜分散和抗生素输送所需的超声参数。同时，我们希望确定刺激候选抗生素的组织渗透的参数。骨组织的器官型模型。该项目将导致在一个充满活力，竞争激烈的群体中培养一名博士生，该群体在新兴工程研究的跨学科领域中具有直接的临床翻译重点。它将使我们能够确定用于军事部署的新型设备/技术的设计参数。它还将与我们以临床为中心的目标密切结合，并将巩固未来研究的合作伙伴关系。