Improved design of effective anti-cancer therapies via multiscale modelling and simulations

通过多尺度建模和模拟改进有效抗癌疗法的设计

• 批准号: 2750802
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2750802
• 关键词: Improved; design; effective; anti; cancer

The aim of this project is to elucidate the interplay between the tumour microenvironment features and the efficacy of blood and drug delivered intravascularly through suitable anti-cancer therapies based on the application of an external (electro-magnetic) field. The student will obtain new mathematical models obtained via homogenisation techniques to describe the biophysical system at hand at a tissue scale level whilst retaining information concerning the tumour microstructure. Model's predictions will support the optimisation of therapy in terms of dosage and scheduling.

这个项目的目的是阐明肿瘤微环境特征与血管内给药的疗效之间的相互作用，通过基于外部(电磁场)应用的合适的抗癌治疗。学生将获得通过均化技术获得的新的数学模型，以在组织级别描述手头的生物物理系统，同时保留有关肿瘤微结构的信息。Model的预测将在剂量和时间安排方面支持治疗的优化。