T cell compartment dynamics following thymectomy

胸腺切除术后 T 细胞区室动力学

• 批准号: 7278504
• 负责人: Brenda M Ogle
• 金额: $ 13.63万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7278504
• 关键词: T lymphocyte; cardiovascular transplantation; cell proliferation; cellular immunity; children; clinical research; human subject; immune response; infant human (0-1 year); longitudinal human study; microarray technology; neonatal intensive care; patient oriented research; thymectomy; transplantation immunology

DESCRIPTION (provided by applicant): My long-term goal is to develop the means to reconstitute immunity. Immune reconstitution would benefit those who suffer immunodeficiency as a result of disease or aging and might be used to generate specific therapies for infection and cancer. Given my background in mathematics, engineering and artificial organ design and my current postdoctoral fellowship in transplantation biology, I am uniquely poised to advance this area of research. I propose here a first step in developing a career directed toward that goal. My proximal goal will be to learn how the T cell compartment of human infants changes in response to thymectomy and T cell depletion carried out at the time of cardiac surgery in infancy. These manipulations should severely distort the physiology of the immune system by removing the source of new T cells, and depleting some of those T cells already present. However, these patients uphold reasonable health. I hypothesize that the relative well being of those who had cardiac transplants or other types of cardiac surgery in infancy results from the expansion of residual T cells and an associated change in functional requirements necessary to elicit an immune response. Testing this hypothesis will allow me to explore natural means of immune reconstitution and evaluate new technologies and methods I have devised to measure immune fitness. This research plan will be complemented by formal training in immunology and by mentorship with Dr. Jeffrey Platt. In addition, an advisory council will be assembled to include Drs. Marilia Cascalho and Mark Litzow. This council will meet on a semiannual basis to evaluate progress in the research plan and the career plan. This program will provide the career development necessary to launch an independent research career in biomedicine.

描述（由申请人提供）：我的长期目标是开发重建免疫力的手段。免疫重建将使那些因疾病或衰老而遭受免疫缺陷的人受益，并可能用于产生针对感染和癌症的特定疗法。鉴于我在数学、工程和人工器官设计方面的背景，以及我目前在移植生物学方面的博士后研究，我有独特的能力来推进这一领域的研究。我在这里提出了朝着这个目标发展职业生涯的第一步。