Industrial Pollutants and Risk of Non-Hodgkins Lymphoma

描述（由申请人提供）：工业污染被怀疑是导致非霍奇金淋巴瘤（NHL）的原因之一，特别是因为这种癌症的发病率在20世纪后半叶急剧上升，略落后于美国工业生产扩大的时期。尽管有一个令人信服的假设，但很少有严谨的研究来检验NHL与特定工业污染物之间的关系。随着桌面地理信息系统（地理信息系统）和工业地点和排放的公共数据库的日益可用和易于使用，这种研究正变得越来越容易执行。研究人员建议对长期环境暴露于工业污染物和NHL风险进行病例对照研究。拟建研究的受试者为来自现有nci赞助的多站点研究的病例（n=855）和对照（n=781），这些研究从洛杉矶县、西雅图和底特律大都会地区招募。居住史将被用来描述30年病原学研究期间受试者的居住地点。将建立一个地理数据库，以进行暴露评估，包含各种来源记录的工业信息，包括地点、操作类型和排放，包括环境保护局的有毒物质释放清单（TRI）和加利福尼亚州、华盛顿州和密歇根州的历史商业目录。我们将研究与特定类型的工业有关的NHL风险，包括石油炼制、纸浆和造纸厂。与特定工业污染物（包括溶剂、多环芳烃和二恶英）相关的风险将在根据排放量和气象数据制定暴露等值线后进行审查。该研究的长期居住历史和潜在混杂因素的丰富现有数据，以及使用GIS开发详细的暴露度量，将使研究人员能够对NHL的环境原因的当前知识状态做出有用的贡献。

DESCRIPTION (provided by applicant): Industrial pollution has been suspected as a cause of non-Hodgkin lymphoma (NHL) particularly because the rates of this cancer increased dramatically during the latter half of the 20th century, lagging slightly behind a period of expanded industrial production in the United States. Despite a compelling hypothesis, there have been few rigorous studies which examined the association between NHL and specific industrial pollutants. Such studies are becoming more readily implemented with the increasing availability and ease-of-use of desktop geographic information systems (GIS) and public databases of industry location and emissions. The investigators propose a case-control study of long-term environmental exposure to industrial pollutants and risk of NHL. Subjects for the proposed study are cases (n=855) and controls (n=781) from an existing NCI-sponsored multi-site study, recruited from Los Angeles County and the Seattle and Detroit metropolitan regions. Residential histories will be used to characterize the location of subjects during the 30-year time period of etiologic interest. A geodatabase will be created for exposure assessment purposes, to contain information on industries including location, operation type, and emissions, as recorded in various sources including the Environmental Protection Agency's Toxics Release Inventory (TRI) and historical business directories from California, Washington, and Michigan States. We will examine NHL risk in relation to specific types of industry, including petroleum refining and pulp and paper mills. The risk associated with specific industrial pollutants of interest, including solvents, polycyclic aromatic hydrocarbons, and dioxins, will be examined after developing exposure contours based on emissions quantities and meterologic data. The study's wealth of existing data on long-term residential history and potential confounders, in addition to the use of GIS for development of detailed exposure metrics, will enable the investigators to make a useful contribution to the current state of knowledge regarding environmental causes of NHL.