The Role of Trauma in the Association between Autism and Psychosis.

自闭症是一种发育性疾病，其特征是社会沟通和互动方面的缺陷，以及限制性和重复性的行为和兴趣。最近的研究发现，自闭症患者患精神疾病的风险增加，这是一种由妄想和幻觉分类的疾病。这可能是因为这两种情况都与创伤（即虐待和忽视经历）有关。创伤是精神病的一个公认的危险因素。此外，自闭症患者经历创伤的可能性很高。本研究的目的是研究创伤在自闭症和精神病之间的关系中可能起的作用。这些研究是由自闭症网络的自闭症患者共同设计的。方法：我将进行一项系统综述，以评估精神病筛查工具对自闭症人群的适用性，因为在自闭症成员的焦点小组会议上强调了口译问题。然后，我将致力于创建一种适合自闭人群使用的精神病测量方法。创伤对自闭症和精神病之间关联的调节作用将首先使用来自青少年大脑认知发展队列的辅助数据进行测试。最后，我将使用新开发的精神病筛查工具，收集成年自闭症人群和非自闭症对照组在自闭症特征、创伤史、认知能力（控制变量）和精神病方面的数据。我将比较两组之间的创伤经历和精神病症状，并使用适度分析测试创伤和自闭症的相互作用是否会显著增加精神病风险。

Introduction: Autism is a developmental condition characterised by deficits in social communication andinteraction, as well as restrictive and repetitive behaviours and interests. Recent research has found thatautistic individuals are at an increased risk of developing psychosis, a condition categorised bydelusional thoughts and hallucinations. This might be because both conditions are associated withtrauma (i.e., abuse and neglect experiences). Trauma is a well-established risk factor for psychosis.Additionally, autistic individuals have a high probability of experiencing trauma. The aim of this researchis to examine the possible role of trauma on the association between autism and psychosis. Thesestudies have been co-designed by autistic individuals of the Autistica Network.Methods: I will conduct a systematic review to evaluate the suitability of psychosis screening instrumentsfor autistic populations, as issues with interpretation were highlighted during a focus group meeting withAutistica members. I will then aim to create a psychosis measure appropriate for use by autisticpopulations. The moderating effect of trauma on the association between autism and psychosis will firstbe tested using secondary data from the Adolescent Brain Cognitive Development cohort. Finally, I willcollect data on an adult autistic population and a non-autistic comparison group on autism traits, traumahistory, cognitive abilities (control variable), and psychosis, using the newly developed psychosisscreening tool. I will compare trauma experiences and psychosis symptoms between the groups and testwhether the interplay of trauma and autism significantly increases the psychosis risk using a moderationanalysis.