The role of cannabinoid receptor expressing interneurons

表达大麻素受体的中间神经元的作用

• 批准号: 7155148
• 负责人: LINDSEY L GLICKFELD
• 金额: $ 2.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-04 至 2008-08-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7155148
• 关键词: cannabinoid receptor; cannabinoids; interneurons; role

DESCRIPTION (provided by applicant): Synaptic inhibition shapes the activity of neuronal populations in space and time. Basket cells, a class of inhibitory interneurons which synapse specifically on the somata of principal cells, provide strong local inhibition to balance afferent excitation. However, the specific means by which they control the activity of their target neurons is poorly understood. This proposal addresses the role of a unique population of basket cells: cannabinoid sensitive basket cells. Our preliminary data suggest that cannabinoid sensitivity defines a distinct network of hippocampal basket cells with unique functional properties. Cannabinoid sensitive basket cells are only weakly and transiently excited such that, under basal conditions, they are responsible for only a minority of inhibition in the hippocampus. However, application of neuromodulators such as opioids can shift the balance of inhibition in favor of cannabinoid sensitive interneurons. Thus, an understanding of the role of these interneurons will help to elucidate how both cannabinoids and opioids modulate network activity. Further, a deeper insight into how a balance between excitation and inhibition is dynamically maintained may contribute to the development of therapies aimed at preventing epileptogenesis in cortical areas.

描述（由申请人提供）：突触抑制在空间和时间上塑造神经元群体的活动。篮状细胞是一类特异性地与主细胞胞体形成突触的抑制性中间神经元，它提供强的局部抑制以平衡传入兴奋。然而，它们控制其靶神经元活动的具体方式却知之甚少。该提案解决了篮细胞的独特群体的作用：大麻素敏感的篮细胞。我们的初步数据表明，大麻素的敏感性定义了一个独特的网络海马篮状细胞具有独特的功能特性。大麻素敏感的篮状细胞仅被微弱和短暂地兴奋，使得在基础条件下，它们仅负责海马中的少数抑制。然而，神经调节剂如阿片类药物的应用可以改变抑制的平衡，有利于大麻素敏感的中间神经元。因此，了解这些中间神经元的作用将有助于阐明大麻素和阿片类药物如何调节网络活动。此外，更深入地了解兴奋和抑制之间的平衡是如何动态维持的，可能有助于开发旨在预防皮质区癫痫发生的治疗方法。