Cortical Regulation of a Whisking CPG

搅拌 CPG 的皮质调节

• 批准号: 7112802
• 负责人: Nathan P Cramer
• 金额: $ 3.09万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-14 至 2009-03-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7112802
• 关键词: action potentials; brain regulatory center; electromyography; laboratory rat; motor cortex; motor neurons; neuroanatomy; neuromuscular function; neuroregulation; neurotransmitter antagonist; predoctoral investigator; psychomotor function; serotonin; vibrissae

DESCRIPTION (provided by applicant): Evidence suggests rhythmic whisker movements in rats are driven by a subcortical central pattern generator (CPG) under control of the whisker motor cortex (wMCx). Additionally, it has been demonstrated that serotonin (5HT) is necessary for whisking. My goal is to investigate a subset of 5HT neurons in the brainstem of adult rats that are likely to comprise an integral part of the whisking CPG. I will investigate the control exerted by the wMCx over this putative CPG component and the impact that the resulting CPG modulation has on whisking frequencies. I propose that the 5HT CPG determines firing frequency of whisker motor units by regulating the delivery of 5HT to motoneurons in the lateral facial nucleus. I further propose that 5HT regulates motor unit firing rates by facilitating a persistent inward current in whisker motoneurons (wMNs) in a dose dependent manner. I will investigate the ability of 5HT to facilitate a dose dependent PIC in whisker motoneurons and its relation to whisker motoneuron firing frequency.

描述（由申请人提供）：证据表明，大鼠的节奏晶须运动是由皮层中央模式发生器（CPG）控制在晶须运动皮层（WMCX）下的。此外，已经证明5-羟色胺（5HT）对于搅拌是必需的。我的目标是研究成年大鼠脑干中5HT神经元的子集，这些神经元可能包括搅拌CpG的组成部分。我将研究WMCX对此推定的CPG组件的控制，以及所得CPG调制对搅拌频率的影响。我建议5HT CPG通过调节5HT向侧面核中的运动神经元的递送来确定晶须电动机单元的发射频率。我进一步提出，5HT通过促进晶须运动神经元（WMN）的持续向内电流来调节运动单位射击速率。我将研究5HT促进晶须运动神经元中剂量依赖性PIC的能力及其与Whisker Motoneuron发射频率的关系。