Neuronal Insulin Signaling and Aging

超出空间 但前提是。 这项研究的长期目标是减少或延缓老年人的残疾和丧失独立性 走路有困难。进行性行走障碍在老年人中很常见，而且缺陷 进行性行走残疾的特点导致步态效率低下。低效的步态与 疲劳，日常生活活动(ADL)难度更大，以及未来身体残疾的风险。在 建议的随机临床试验，具体目的是确定是否对老年人进展性 行走障碍，一种专门为提高行走中的运动技能而设计的干预措施将改善 提高效率，提高步态速度，降低身体残疾的风险，改善身体机能和体能 活动。一种新开发的基于技能的步态训练干预措施解决了 老年人进行性行走障碍。基于技能的步态训练的随机临床试验 与传统步态训练相比，进行性步行障碍老年人的步态训练包括步态训练 每周两次干预，持续12周，根据绩效和自我报告结果预先测量 (基线)和干预后。这项研究将在4个地点进行，每个地点超过一年。 参与者将在现场随机接受基于技能或传统步态的训练。基于技能的步态训练是 预计在提高步态效率和增加步态方面比传统步态训练更有效 速度，与逐渐行走的老年人减少与行动能力相关的残疾有关 残疾。将使用步态特征的临床和实验室测量来解决次要问题 目的：解释干预后老年人步态效率和步速的变化。其他内容 将使用基于绩效的和自我报告的功能、耐力和体力活动的测量方法 解决次要目标，以确定提高步态效率是否与改善有关 身体功能和降低身体残疾的风险。

EXCEED THE SPACE PROVIDED. The long-term objective of the study is to reduce or delay disability and loss of independence in older adults with walking difficulty. Progressive walking disability is common among older adults, and the deficits characteristic of progressive walking disability contribute to gait inefficiency. Inefficient gait isassociated with fatigue, greater difficulty in activities of daily living (ADL), and risk for future physical disability. In the proposed randomized clinical trial, the specific aim is to determine if for older persons with progressive walking disability, an intervention specifically designed to increase motor skill in walking will improvegait efficiency, increase gait speed, reduce risk for physical disability, and improve physical function and physical activity. A newly developed skill-based gait training intervention addresses the problems characteristic of progressive walking disability of older adults. The randomized clinical trial of skill-based gait training compared to traditional gait training for older persons with progressive walking disability involves gait training intervention 2 times a week for 12 weeks with performance-based and self-report outcomes measured pre (baseline) and post intervention. The study will be conducted at 4 sites, over one year at each site. Participants will be randomized to skill-based or traditional gait training within site. Skill-based gait training is expected to be more effective than traditional gait training in improving gait efficiency and increasing gait speed, associated with reducing mobility-related disability in older persons with progressive walking disability. Clinical and laboratory measure of gait characteristics will be used to address thesecondary objective, to explain changes in gait efficiency and gait speed of older adults after intervention. Additional performance-based and self-report measures of function, endurance, and physical activity will be used to address the secondary objective to determine if improving gait efficiency is associated with improved physical function and reduced risk for physical disability.