In-Vivo Spectroscopy/Imaging System PharmaScan 47/16

描述(由申请人提供)： 在这项提案中，我们要求为Bruker 4.7/16 PharmaScan啮齿动物MRI/MRS扫描仪提供资金。在过去的十年中，MRI和MRS(磁共振成像和光谱学)在药物发现、基础临床前研究以及假说驱动的生物医学研究中显示出巨大的前景。这些快速发展的技术的优点是它们的非侵入性，以及可以监测的丰富的解剖、生理和生化参数。在过去的一年里，麻醉学系建立了一个生物医学MRS实验室，配备了两个高分辨率的布鲁克核磁共振系统(500 MHz窄孔和300 MHz宽孔磁铁)，用于组织提取液、细胞培养和灌流器官的体外实验。尽管需求很高，但科罗拉多大学仍然没有任何针对动物的MRS/MRI能力；我们现有的成像设备不足以支持我们研究人员的许多需求。UCHSC有几名在动物MRI/MRS扫描仪方面拥有丰富经验的教职员工，他们将负责所要求的PharmaScan的操作和维护。具体地说，在UCHSC拥有第一台动物扫描仪，我们将能够(A)支持与小动物相关的基础和翻译研究的所有研究人员；(B)共享成像研究资源，供科罗拉多州的部门和机构内部使用；(C)培训小动物成像科学和技术方面的专业和技术支持人员；(D)在分子成像领域开发新的尖端方法。所要求的PharmaScan将放置在UCHSC Fitzsimons新校区研究综合体I的新Vivarum的MRS/MRI套件中。这个位置将是理想的，因为动物不需要被从动物设施中移出进行MRS/MRI研究。麻醉学、药理学和癌症中心的部门已经投入了足够的财政资源来建立、运行和维护该仪器。这是一个非常需要的仪器，将为科罗拉多州和周围落基山地区的活体研究提供一个重要的地区性设施。

DESCRIPTION (provided by applicant): In this proposal we request funding for a Bruker 4.7/16 PharmaScan rodent MRI/MRS scanner. In the last decade, MRI and MRS (magnetic resonance imaging and spectroscopy) have shown great promise in drug discovery, basic pre-clinical investigations, as well as hypothesis-driven biomedical research. The advantages of these rapidly developing techniques are their non-invasive nature and the abundance of anatomical, physiological, and biochemical parameters that can be monitored. In the past year, the Department of Anesthesiology has established a Biomedical MRS laboratory with two high-resolution Bruker NMR systems (a 500 MHz narrow-bore and a 300 MHz wide-bore magnets) for ex vivo experiments on tissue extracts, cell cultures, and perfused organs. Although there is a high demand, the University of Colorado still does not have any MRS/MRI capabilities for animals; our existing imaging equipment is not sufficient to support the many needs of our investigators. UCHSC has several faculty members with extensive experience with animal MRI/MRS scanners who will be responsible for operation and maintenance of the requested PharmaScan. Specifically, having the first animal scanner at UCHSC, we will be able (a) to support all investigators of basic and translational research which is related to small animals; (b) to share imaging research resources to be used intradepartmentally and intrainstitutionally in Colorado; (c) to train both professional and technical support personnel in the science and techniques of small animal imaging; (d) to develop novel sophisticated methods in the area of molecular imaging. The requested PharmaScan will be placed in the MRS/MRI suite of the new Vivarium in Research Complex I on UCHSC's new Fitzsimons campus. This location will be ideal since animals will not have to be removed from the animal facility for MRS/MRI studies. The Departments of Anesthesiology, Pharmacology and the Cancer Center have committed sufficient financial resources for setting up, running and maintaining the instrument. This is a much needed instrumentation and will provide an important regional facility for in vivo research in Colorado and the surrounding Rocky Mountain region.