In-Vivo Spectroscopy/Imaging System PharmaScan 47/16

描述（由申请人提供）： 在本提案中，我们申请为Bruker 4.7/16 PharmaScan啮齿动物MRI/MRS扫描仪提供资金。在过去的十年中，MRI和MRS（磁共振成像和光谱）在药物发现，基础临床前研究以及假设驱动的生物医学研究中显示出巨大的前景。这些快速发展的技术的优点是它们的非侵入性和丰富的解剖，生理和生化参数，可以监测。在过去的一年里，麻醉学系建立了一个生物医学MRS实验室，该实验室配备了两个高分辨率的布鲁克NMR系统（500 MHz窄孔和300 MHz宽孔磁体），用于组织提取物、细胞培养物和灌注器官的离体实验。虽然有很高的需求，科罗拉多大学仍然没有任何动物的MRS/MRI能力;我们现有的成像设备不足以支持我们的研究人员的许多需求。UCHSC有几名具有丰富动物MRI/MRS扫描仪经验的教员，他们将负责操作和维护所要求的PharmaScan。具体而言，在UCHSC拥有第一台动物扫描仪，我们将能够（a）支持所有与小动物有关的基础和转化研究的研究人员;（B）共享成像研究资源，供科罗拉多的部门内和机构内使用;（c）培训小动物成像科学和技术方面的专业和技术支持人员;（d）在分子成像领域开发新的先进方法。所要求的PharmaScan将被放置在UCHSC新Fitzsimons校区研究综合体I的新动物园的MRS/MRI套件中。该位置将是理想的，因为动物不必从动物设施中取出进行MRS/MRI研究。麻醉学系、药理学系和癌症中心已承诺提供足够的财政资源来建立、运行和维护该仪器。这是一个非常需要的仪器，并将提供一个重要的区域设施，在体内研究在科罗拉多和周围的落基山脉地区。

DESCRIPTION (provided by applicant): In this proposal we request funding for a Bruker 4.7/16 PharmaScan rodent MRI/MRS scanner. In the last decade, MRI and MRS (magnetic resonance imaging and spectroscopy) have shown great promise in drug discovery, basic pre-clinical investigations, as well as hypothesis-driven biomedical research. The advantages of these rapidly developing techniques are their non-invasive nature and the abundance of anatomical, physiological, and biochemical parameters that can be monitored. In the past year, the Department of Anesthesiology has established a Biomedical MRS laboratory with two high-resolution Bruker NMR systems (a 500 MHz narrow-bore and a 300 MHz wide-bore magnets) for ex vivo experiments on tissue extracts, cell cultures, and perfused organs. Although there is a high demand, the University of Colorado still does not have any MRS/MRI capabilities for animals; our existing imaging equipment is not sufficient to support the many needs of our investigators. UCHSC has several faculty members with extensive experience with animal MRI/MRS scanners who will be responsible for operation and maintenance of the requested PharmaScan. Specifically, having the first animal scanner at UCHSC, we will be able (a) to support all investigators of basic and translational research which is related to small animals; (b) to share imaging research resources to be used intradepartmentally and intrainstitutionally in Colorado; (c) to train both professional and technical support personnel in the science and techniques of small animal imaging; (d) to develop novel sophisticated methods in the area of molecular imaging. The requested PharmaScan will be placed in the MRS/MRI suite of the new Vivarium in Research Complex I on UCHSC's new Fitzsimons campus. This location will be ideal since animals will not have to be removed from the animal facility for MRS/MRI studies. The Departments of Anesthesiology, Pharmacology and the Cancer Center have committed sufficient financial resources for setting up, running and maintaining the instrument. This is a much needed instrumentation and will provide an important regional facility for in vivo research in Colorado and the surrounding Rocky Mountain region.