Functional genomics approaches to define new drug-targets for cancer therapy

功能基因组学方法定义癌症治疗新药物靶点

• 批准号: nhmrc : 575581
• 负责人: Dr Ian Majewski
• 金额: $ 24.99万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-genomics-approaches-cancer-therapy/116233
• 关键词: Functional; genomics; approaches; define; new

Cancer is a deadly disease that results from the accumulation of genetic mistakes (mutations) that encourage cells to divide and spread. There are some key mutations that occur in many different types of cancer. My project aims to exploit this common blueprint to design drugs that will selectively kill cancer cells, while leaving normal cells unharmed. We will identify new drug targets for the treatment of breast, colon and lung cancer and assess these targets in a variety of model systems.

癌症是一种致命的疾病，它是由鼓励细胞分裂和扩散的遗传错误（突变）的积累引起的。有一些关键突变发生在许多不同类型的癌症中。我的项目旨在利用这一共同蓝图来设计药物，选择性地杀死癌细胞，同时不伤害正常细胞。我们将确定用于治疗乳腺癌、结肠癌和肺癌的新药靶点，并在各种模型系统中评估这些靶点。