Functional impairment of mouse and human dendritic cells following Systemic Inflammatory Response Syndrome (SIRS): towards novel diagnostics and treatments

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Severe infections, trauma or stroke cause Systemic Inflammatory Response Syndrome (SIRS). SIRS patients often succumb to otherwise innocuous infections because SIRS induces a long state of immune suppression. We think an underlying mechanisms is the functional impairment of a critical immune cell type called dendritic cells (DC). The goal of this grant is to develop tools to measure, predict and prevent the formation of these 'paralysed DC' to restore a healthy immune system in SIRS patients.