Total Synthesis of Communesin B

描述（由申请人提供）：本研究计划的具体目标是吲哚生物碱communesin B的全合成。公社蛋白B是一种具有广泛生物活性的天然产物，其具有两个邻位四级中心和两个嵌入七环框架内的胺部分。迄今为止尚未报道全合成。该化合物的成功合成将代表生物碱合成领域的重要进展。communesin B合成的关键步骤是采用吲哚衍生物作为亲核试剂的Mo-、Ir-或W-催化的不对称烯丙基烷基化（AAA）反应。吲哚类亲核试剂在AAA反应中的使用还没有先例，并且将是当前AAA技术的显著扩展。

DESCRIPTION (provided by applicant): The specific goal of this research proposal is the total synthesis of the indoline alkaloid communesin B. Communesin B is a broadly biologically active natural product that posseses two vicinal quaternary centers and two aminal moeities embedded within a heptacyclic framework. There have been no reported total syntheses to date. The successful synthesis of this compound would represent an important advance in the field of alkaloid synthesis. The key step in the synthesis of communesin B would be a Mo-, Ir-, or W- catalyzed asymmetric allylic alkylation (AAA) reaction which will employ indole derivatives as the nucleophile. The use of indoles nucleophiles in the AAA reaction has not been precedented and would be a significant extension of the current AAA technology.