Hypervalent iodine reagents for late-stage functionalisation

用于后期功能化的高价碘试剂

• 批准号: 2763223
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2763223
• 关键词: Hypervalent; iodine; reagents; late; stage

Heteroatom alkylation is one of the most widely used reactions in medicinal chemistry. However, traditional approaches (Williamson/Mitsunobu reactions; metal-catalysed cross-coupling) are limited and there is a need for reliable methods for quick and selective alkylation of hindered nucleophiles. The aim of this PhD project is to address this challenge and develop new hypervalent iodine reagents for late-stage alkylation. The specific focus of the project will be defined in collaboration with the successful applicant.

杂原子烷基化反应是药物化学中应用最广泛的反应之一。然而，传统的方法(Williamson/Mitsunobu反应；金属催化的交叉偶联)是有限的，需要可靠的方法来快速和选择性地使受阻的亲核试剂发生烷基化反应。该博士项目的目的是应对这一挑战，并开发用于后期烷基化反应的新的高价碘试剂。该项目的具体重点将与成功的申请者合作确定。