Laser Spectrometry Development for Isotopic Analysis in Environmental and Medical Applications

环境和医疗应用中同位素分析的激光光谱测定法开发

基本信息

  • 批准号:
    2764502
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Studentship
  • 财政年份:
    2022
  • 资助国家:
    英国
  • 起止时间:
    2022 至 无数据
  • 项目状态:
    已结题

项目摘要

will investigate the potential towards IR-absorption laser spectrometry for traceability of low-level very high precision measurements of stable isotopes and radiocarbon in carbon dioxide and methane, relevant for environmental monitoring and drug discovery applications. Carbon-14 in particular is an ideal radioactive tracer for many processes and this project will culminate in the development of these measurements. (1) As the UK transitions towards 'net zero carbon', new and improved methods of verifying industrial emissions and atmospheric composition will be required. Atmospheric C-14 measurements allow for the estimation of the fossil-fuel fraction of CO2 and CH4. (2) C-14 as a tracer is vital for the rapid and cost-effective development of drugs, notably for the treatment of cancer. It is used in the early efficacy stage of drug development to understand how the human body will handle the drug in terms of the absorption, distribution, metabolism and elimination (ADME).
将研究红外吸收激光光谱法的潜力,用于二氧化碳和甲烷中稳定同位素和放射性碳的低水平非常高精度测量的可追溯性,与环境监测和药物发现应用有关。特别是碳-14是许多过程的理想放射性示踪剂,该项目将最终发展这些测量。(1)随着英国向“净零碳”过渡,将需要新的和改进的方法来验证工业排放和大气成分。通过对大气中碳14的测量,可以估计化石燃料中二氧化碳和甲烷的比例。(2)C-14作为示踪剂对于快速和具有成本效益的药物开发至关重要,特别是用于治疗癌症。它用于药物开发的早期疗效阶段,以了解人体在吸收,分布,代谢和消除(ADME)方面如何处理药物。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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其他文献

Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
  • DOI:
    10.1002/cam4.5377
  • 发表时间:
    2023-03
  • 期刊:
  • 影响因子:
    4
  • 作者:
  • 通讯作者:
Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
  • DOI:
    10.1186/s12889-023-15027-w
  • 发表时间:
    2023-03-23
  • 期刊:
  • 影响因子:
    4.5
  • 作者:
  • 通讯作者:
The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
  • DOI:
    10.1007/s10067-023-06584-x
  • 发表时间:
    2023-07
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
  • 通讯作者:
ElasticBLAST: accelerating sequence search via cloud computing.
ElasticBLAST:通过云计算加速序列搜索。
  • DOI:
    10.1186/s12859-023-05245-9
  • 发表时间:
    2023-03-26
  • 期刊:
  • 影响因子:
    3
  • 作者:
  • 通讯作者:
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
使用通过嵌段共聚物自组装制造的 2D 金纳米结构阵列放大 EQCM-D 检测细胞外囊泡。
  • DOI:
    10.1039/d2nh00424k
  • 发表时间:
    2023-03-27
  • 期刊:
  • 影响因子:
    9.7
  • 作者:
  • 通讯作者:

的其他文献

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{{ truncateString('', 18)}}的其他基金

An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
  • 批准号:
    2901954
  • 财政年份:
    2028
  • 资助金额:
    --
  • 项目类别:
    Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
  • 批准号:
    2896097
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
  • 批准号:
    2780268
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
  • 批准号:
    2908918
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
  • 批准号:
    2908693
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
  • 批准号:
    2908917
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
  • 批准号:
    2879438
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
  • 批准号:
    2890513
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
CDT year 1 so TBC in Oct 2024
CDT 第 1 年,预计 2024 年 10 月
  • 批准号:
    2879865
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
  • 批准号:
    2876993
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship

相似海外基金

Development of laser-based Mass Spectrometry devices for accelerated cancer pathology assessment
开发基于激光的质谱设备以加速癌症病理学评估
  • 批准号:
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  • 财政年份:
    2021
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    --
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Development of laser-based Mass Spectrometry devices for accelerated cancer pathology assessment
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  • 批准号:
    535056-2019
  • 财政年份:
    2020
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Development of a new direct mass analysis technique for trace liquid organic matter by combining aeromicelle and water matrix assisted laser desorption and ionization mass spectrometry
结合气胶束和水基质辅助激光解吸和电离质谱法,开发痕量液体有机物的新型直接质量分析技术
  • 批准号:
    20K05552
  • 财政年份:
    2020
  • 资助金额:
    --
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    Grant-in-Aid for Scientific Research (C)
Development of laser-based Mass Spectrometry devices for accelerated cancer pathology assessment
开发基于激光的质谱设备以加速癌症病理学评估
  • 批准号:
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  • 财政年份:
    2019
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Development and Application of Femtosecond Laser-Ionization Imaging Accelerator Mass Spectrometry
飞秒激光电离成像加速器质谱仪的研制与应用
  • 批准号:
    515715-2017
  • 财政年份:
    2017
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    Alexander Graham Bell Canada Graduate Scholarships - Master's
Development of infrared laser ionization techniques for high throughput mass spectrometry of membrane proteins
开发用于膜蛋白高通量质谱分析的红外激光电离技术
  • 批准号:
    16H03291
  • 财政年份:
    2016
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Multiplexed Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry Imaging (MSI) of Breast Cancer, Prostate Cancer, and Colorectal Cancer for Proteomic and Metabolomic Biomarker Discovery, Validation, and Verification for the Development of
乳腺癌、前列腺癌和结直肠癌的多重基质辅助激光解吸/电离 (MALDI) 质谱成像 (MSI),用于蛋白质组学和代谢组学生物标志物的发现、验证和验证,以开发
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Development of a laser-ablation C-14 accelerator mass spectrometry system aiming for direct mapping measurements of C-14
开发激光烧蚀 C-14 加速器质谱系统,旨在直接测量 C-14
  • 批准号:
    26600138
  • 财政年份:
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开发用于膜蛋白高通量质谱分析的红外激光大气压电离技术
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Collaborative Research: Analytical Techniques and Software: Development of CyberInfrastructure to Support Laser-Ablation ICP Mass Spectrometry
合作研究:分析技术和软件:开发支持激光烧蚀 ICP 质谱分析的网络基础设施
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    0930166
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
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