COGNITIVE AND EMOTIONAL RESPONSES TO AN HPV DIAGNOSIS IN MEN

男性 HPV 诊断的认知和情感反应

• 批准号: 7138073
• 负责人: ELLEN M. DALEY
• 金额: $ 41.87万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-18 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7138073
• 关键词: behavior; cervix neoplasms; clinical research; diagnosis; infection; neoplasm /cancer; prevention; sex

DESCRIPTION (provided by applicant): HPV, a sexually transmitted infection, is strongly associated with invasive cervical, vulvar, and anal cancers in women, penile and anal cancers in men, and anogenital warts in both men and women. Internationally, cervical cancer is the second most common cancer among women. Recent research suggests that the sexual behavior of the male partner may be as or more important than a woman's personal sexual behavior in predicting her risk of HPV infection and cervical disease. Despite a high HPV prevalence (lifetime approximately 50%) the majority of men and women lack knowledge about HPV and its causal relationship with genital warts, cervical dysplasia, and cancer. The IOM recently highlighted lack of communication and secrecy as major contributors to the 'hidden epidemic1 of STIs. Unfortunately little is known about men's knowledge of HPV and their response to an HPV test result due to a general lack of HPV research among men. This has severely limited our ability to design effective strategies to control HPV in men as well as in women. To achieve the goal of reducing HPV infection and associated disease it is imperative that we educate both sexes about HPV and its sequelae. The purpose of this study is to further our understanding of men's cognitive, emotional, and behavioral responses to an HPV test result so that effective programs can be developed to reduce cervical cancer and HPV related disease in both sexes. We are uniquely positioned to fill this information gap by collaborating with a currently funded HPV natural history study in men, (The HIM Study CA098803; PI Dr. Giuliano) where 1000 predominantly heterosexual US men are tested repeatedly for genital HPV over a 5 year period. Our proposed study, the Cognitive and Emotional Response Study (CER Study) will assess the cognitive, emotional, and behavioral responses to an HPV test result in men. We propose a prospective study implementing 4 surveys, completed by 500 HIM Study participants every 6 months over a 2 year period. Our study is unique in that it will be the first to prospectively assess reactions to HPV results among US men; cost-effective as it utilizes the enrollment, HPV testing and follow-up infrastructure of a cohort study currently underway; timely in that it will identify behaviors and responses to HPV test results at a time when HPV prevention vaccines are being introduced. These data will assist in the planning, implementation, and evaluation of interventions to reduce HPV infection in both sexes.

描述（由申请人提供）：HPV 是一种性传播感染，与女性的侵袭性宫颈癌、外阴癌和肛门癌、男性的阴茎癌和肛门癌以及男性和女性的肛门生殖器疣密切相关。在国际上，宫颈癌是女性第二大常见癌症。最近的研究表明，在预测 HPV 感染和宫颈疾病的风险方面，男性伴侣的性行为可能与女性的个人性行为一样重要，甚至更重要。尽管 HPV 患病率很高（一生中约 50%），但大多数男性和女性缺乏有关 HPV 及其与尖锐湿疣、宫颈发育不良和癌症之间因果关系的知识。国际移民组织最近强调，缺乏沟通和保密是导致性传播感染“隐性流行”的主要原因。不幸的是，由于男性普遍缺乏 HPV 研究，人们对男性 HPV 的了解以及他们对 HPV 检测结果的反应知之甚少。这严重限制了我们设计有效策略来控制男性和女性 HPV 的能力。为了实现减少 HPV 感染和相关疾病的目标，我们必须对男女进行有关 HPV 及其后遗症的教育。本研究的目的是进一步了解男性对 HPV 检测结果的认知、情绪和行为反应，以便制定有效的计划来减少两性的宫颈癌和 HPV 相关疾病。我们拥有独特的优势，通过与目前资助的男性 HPV 自然历史研究（HIM 研究 CA098803；PI Dr. Giuliano）合作来填补这一信息空白，该研究对 1000 名以异性恋为主的美国男性在 5 年时间内进行了生殖器 HPV 反复检测。我们提出的认知和情绪反应研究（CER 研究）将评估男性对 HPV 检测结果的认知、情绪和行为反应。我们建议开展一项前瞻性研究，该研究实施 4 项调查，由 500 名 HIM 研究参与者在 2 年内每 6 个月完成一次。我们的研究的独特之处在于，它将是第一个前瞻性评估美国男性对 HPV 结果的反应的研究。具有成本效益，因为它利用了目前正在进行的一项队列研究的入组、HPV 检测和后续基础设施；及时，因为它将在引入 HPV 预防疫苗时识别行为和对 HPV 检测结果的反应。这些数据将有助于规划、实施和评估减少两性 HPV 感染的干预措施。