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Functional significance of subcellular localisation of viral 3C protease in rhinovirus pathogenesis

Functional significance of subcellular localisation of viral 3C protease in rhinovirus pathogenesis
病毒3C蛋白酶亚细胞定位在鼻病毒发病机制中的功能意义
批准号:
nhmrc : 545844
负责人:
Prof Reena Ghildyal
金额:
$40.91万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2013-12-31

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中文摘要
翻译
鼻病毒(RV)感染是病毒引起的哮喘发作和普通感冒的主要原因,造成显著的发病率和死亡率。全世界哮喘的发病率正在增加,迫切需要新的策略来减少rv相关疾病。我们在感染宿主细胞的核室中观察到RV 3C蛋白酶,并提出确定其在RV发病机制中与哮喘治疗相关的意义。
英文摘要
Rhinovirus (RV) infections are the major cause of virus induced asthma attacks and common colds, causing significant morbidity and mortality. The incidence of asthma is increasing worldwide with new strategies urgently needed to reduce RV-associated disease. We have observed RV 3C protease in the nuclear compartment of infected host cells and propose to determine its significance in RV pathogenesis with relevance to asthma therapies.
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