Functional significance of subcellular localisation of viral 3C protease in rhinovirus pathogenesis
Functional significance of subcellular localisation of viral 3C protease in rhinovirus pathogenesis
病毒3C蛋白酶亚细胞定位在鼻病毒发病机制中的功能意义
批准号：
nhmrc : 545844
负责人：
Prof Reena Ghildyal
金额：
$40.91万
依托单位：
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2009
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2009-01-01 至 2013-12-31
中文摘要
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英文摘要
Rhinovirus (RV) infections are the major cause of virus induced asthma attacks and common colds, causing significant morbidity and mortality. The incidence of asthma is increasing worldwide with new strategies urgently needed to reduce RV-associated disease. We have observed RV 3C protease in the nuclear compartment of infected host cells and propose to determine its significance in RV pathogenesis with relevance to asthma therapies.
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