Deciphering lipid-RNA nanocarrier structure upon RNA complexation

破译RNA复合后的脂质-RNA纳米载体结构

• 批准号: DP240101825
• 负责人: Dr Jiali Zhai
• 金额: $ 35.33万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101825
• 关键词: Deciphering; lipid; RNA; nanocarrier; structure

This project aims to decipher the nanostructure evolution, at a millisecond timescale, of lipid self-assembly upon coupling with RNAs and track the nanocarrier structural changes induced by biologically relevant acidic environments. This project will generate new knowledge of the interplay between the self-assembled lipid-RNA nanostructures and cellular objects for successful payload release. The expected outcome of this project is identification of the fundamental mechanisms of lipid-RNA molecular self-assembly and intracellular nucleic acid delivery. This should provide significant advances in the field of lipid nanoparticle engineering for the delivery of RNA therapeutics.

该项目旨在破译与 RNA 偶联时脂质自组装在毫秒级的纳米结构演化，并追踪生物相关酸性环境引起的纳米载体结构变化。该项目将产生关于自组装脂质-RNA 纳米结构和细胞物体之间相互作用的新知识，以成功释放有效载荷。该项目的预期成果是鉴定脂质-RNA 分子自组装和细胞内核酸递送的基本机制。这将为用于 RNA 治疗的脂质纳米颗粒工程领域带来重大进展。