Deciphering lipid-RNA nanocarrier structure upon RNA complexation

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This project aims to decipher the nanostructure evolution, at a millisecond timescale, of lipid self-assembly upon coupling with RNAs and track the nanocarrier structural changes induced by biologically relevant acidic environments. This project will generate new knowledge of the interplay between the self-assembled lipid-RNA nanostructures and cellular objects for successful payload release. The expected outcome of this project is identification of the fundamental mechanisms of lipid-RNA molecular self-assembly and intracellular nucleic acid delivery. This should provide significant advances in the field of lipid nanoparticle engineering for the delivery of RNA therapeutics.