权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Exploring how chemical and nanostructural functionalities of short designed peptide hydrogels control early host immune responses

探索短肽水凝胶的化学和纳米结构功能如何控制早期宿主免疫反应

基本信息

批准号：
2775225
负责人：
金额：
--
依托单位：
University of Manchester
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2775225
关键词：
Exploring how chemical nanostructural functionalities

项目摘要

This project will exploit new ways of working in the life science-physics interface by engaging in the new challenge of exploring how to control early immune responses of short, designed, antimicrobial peptide hydrogels. This area of work has so far been led by physical research over the past 10 years with over 20 journal publications. To further develop these self-assembled bionanomaterials and seek their applications in regenerative medicine and drug delivery, it is highly necessary to train new skills from both physical sciences and core biosciences (cell biochemistry, physiology, immunity), in conjunction with a more niche area of tissue engineering - a theme that has been advocated by BBSRC for decades. This project will train the new PhD student to understand how immune responses act at molecular, cellular and physiological levels to influence physiological and pathophysiological processes. The student will also develop awareness and skills relating to the NC3Rs (i.e. Replacement, Refinement & Reduction of Animals in Research) as well as key skills pertaining to the BBSRC commitment to non-animal technologies in the development of biotechnologies and testing systems that better predict human and animal responses, and the environmental effects of chemicals and new nanostructure entities.

该项目将通过探索如何控制短的、设计的、抗菌肽水凝胶的早期免疫反应的新挑战，在生命科学-物理界面中探索新的工作方式。在过去的10年里，这一领域的工作一直由物理研究主导，在20多家杂志上发表过论文。为了进一步开发这些自组装的生物纳米材料，并寻求其在再生医学和药物输送方面的应用，非常有必要从物理科学和核心生物科学（细胞生物化学、生理学、免疫）两方面培养新技能，并结合组织工程这一更利基的领域——这是BBSRC几十年来一直倡导的主题。该项目将训练新博士生了解免疫反应如何在分子、细胞和生理水平上影响生理和病理生理过程。学生还将培养与NC3Rs（即研究中动物的替代、改良和减少）相关的意识和技能，以及与BBSRC承诺有关的关键技能，即在生物技术和测试系统的开发中使用非动物技术，以更好地预测人类和动物的反应，以及化学品和新纳米结构实体的环境影响。