High-throughput microfluidic single-cell analysis using bioimpedance and dielectric spectroscopy to gain insights into sub-cellular structure and mech

使用生物阻抗和介电谱进行高通量微流控单细胞分析，以深入了解亚细胞结构和机制

• 批准号: 2775607
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2775607
• 关键词: throughput; microfluidic; single; cell; analysis

This project combines two different platforms of expertise across disciplines to establish a new transformative technology (theme 1) for rapid and potentially low-cost automated cell analysis.At Manchester we are actively researching bioimpedance spectroscopy to support food production and precision agriculture, for example our leading work on factory-deployable non-contact induction systems to measure fruit ripening, damage, bruising, and quality control. This new international collaboration with Melbourne's expertise in microfluidic instrumentation opens an exciting avenue where we can potentially analyse bioimpedance at the cellular level. The future prospect is a class of portable desktop or 'lab-in-the-field' instruments capable of simple cellular analysis - cell-sizes, cell-counting, integrity, identification, etc - at a relatively low-cost. This could enable a range of new applications across the grand challenges identified by BBSRC, from affordable human, animal, and plant health solutions to process control in biobased industrial processes, previously out of reach due to cost or facility access.

该项目结合了两个不同的跨学科专业平台，建立了一种新的变革性技术（主题1），用于快速和潜在的低成本自动化细胞分析。在曼彻斯特，我们正在积极研究生物阻抗谱，以支持食品生产和精准农业，例如我们在工厂部署的非接触式感应系统方面的领先工作，用于测量水果成熟，损伤，瘀伤和质量控制。与墨尔本在微流体仪器方面的专业知识的这种新的国际合作开辟了一条令人兴奋的途径，我们可以在细胞水平上分析生物阻抗。未来的前景是一类便携式台式或“现场实验室”仪器，其能够以相对低的成本进行简单的细胞分析-细胞大小、细胞计数、完整性、识别等。这可以在BBSRC确定的重大挑战中实现一系列新的应用，从负担得起的人类，动物和植物健康解决方案到生物基工业过程中的过程控制，以前由于成本或设施访问而无法实现。