Engineering bio-recorders to permanently record environmental events in the yeast genome

工程生物记录仪可永久记录酵母基因组中的环境事件

• 批准号: 2775622
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2775622
• 关键词: Engineering; bio; recorders; permanently; record

We aim to engineer cellular recorders in yeast to track intracellular and extracelluar biological events over time across living cells and cell populations. This is a hardcore synthetic biology project, which is a priority area for the BBSRC. It will develop novel transformative technologies which allow researchers to capture environmental and cellular events by faithfully recording them into the genome. The project also involves mathematical and computational approaches to record, retrieve and error-correct biological and digital information. In terms of applications, biorecorders can be deployed to real time monitor human health (healthy country), chemical and biological threats (resilient country) and environmental impacts over an extended period of time.

我们的目标是在酵母中设计细胞记录器，以跟踪活细胞和细胞群中随时间推移的细胞内和细胞外生物事件。这是一个核心合成生物学项目，是BBSRC的优先领域。它将开发新的变革性技术，使研究人员能够通过忠实地将其记录到基因组中来捕获环境和细胞事件。该项目还涉及数学和计算方法来记录，检索和纠正错误的生物和数字信息。在应用方面，生物记录仪可用于真实的时间监测人类健康（健康国家）、化学和生物威胁（复原国家）以及长期环境影响。