Single Chain Antibody Core
Single Chain Antibody Core
批准号:
6942229
负责人:
Bryan R. G. Williams
金额:
$6.77万
依托单位国家:
美国
项目类别:
财政年份:
2004
资助国家:
美国
项目状态:
已结题
起止时间:
2004-07-12 至 2010-03-31
中文摘要
这个核心将开发高选择性、高亲和力的抗体来研究协调的细胞信号。
将产生抗体来区分靶标酶的活性形式。抗体将被分离出来
从已建立的c DNA,核糖体上展示的单链免疫文库。这个图书馆将是
使用模拟关键信号蛋白的效应区或全长的修饰多肽进行筛选
激活的蛋白质。这一目标将通过两个具体目标实现:
1.为了维护免疫库,
2.分离抗特异性抗原单链抗体。
英文摘要
This core will develop highly selective, high affinity antibodies to investigate coordinated cell signaling.
Antibodies will be generated to distinguish active forms of target enzymes. The antibodies will be isolated
from an established cDNA, single-chain immune library displayed on ribosomes. This library will be
screened using modified peptides that mimic the effector regions of key signal proteins or, alternatively, fulllength
activated proteins. This objective will be fulfilled in two specific aims:
1. To maintain immune libraries,
2. To isolate single-chain antibodies to specific antigens.
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会议论文
INTEGRATED PROTEOM WORKS SYSTEM: CANCER, PROSTATE & BREAST CANCER
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批准号:7166142
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项目类别:
-
资助金额:$5.59万
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财政年份:2005
-
负责人:Bryan R. G. Williams
-
依托单位:
INTEGRATED PROTEOM WORKS SYSTEM: CARDIOVASCULAR DISEASE
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批准号:7166141
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项目类别:
-
资助金额:$10.07万
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财政年份:2005
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负责人:Bryan R. G. Williams
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依托单位:
INTEGRATED PROTEOM WORKS SYSTEM: ASTHMA, IMMUNOLOGY
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批准号:7166143
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项目类别:
-
资助金额:$6.71万
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财政年份:2005
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负责人:Bryan R. G. Williams
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依托单位:
Pilot: Regulation of Obesity and ER Stress by Salicylates
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批准号:7007855
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项目类别:
-
资助金额:$25.0万
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财政年份:2005
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负责人:Bryan R. G. Williams
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依托单位:
Integrated Proteom Works System
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批准号:6877216
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项目类别:
-
资助金额:$22.37万
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财政年份:2005
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负责人:Bryan R. G. Williams
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依托单位:
cDNA Microarray Facility Core
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批准号:6942228
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项目类别:
-
资助金额:$9.91万
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财政年份:2004
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负责人:Bryan R. G. Williams
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依托单位:
Alternate Pathways for Interferon and Cytokine Signaling
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批准号:6942224
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项目类别:
-
资助金额:$25.57万
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财政年份:2004
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负责人:Bryan R. G. Williams
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依托单位:
ALTERNATE PATHWAYS FOR INTERFERON AND CYTOKINE SIGNALING
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批准号:6580345
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项目类别:
-
资助金额:$9.16万
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财政年份:2002
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负责人:Bryan R. G. Williams
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依托单位:
Mechanisms in Wilms Tumorigenesis
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批准号:6802921
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项目类别:
-
资助金额:$27.64万
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财政年份:2001
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负责人:Bryan R. G. Williams
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依托单位:
Mechanisms in Wilms Tumorigenesis
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批准号:6399208
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项目类别:
-
资助金额:$27.64万
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财政年份:2001
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负责人:Bryan R. G. Williams
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依托单位:
ALTERNATE PATHWAYS FOR INTERFERON AND CYTOKINE SIGNALING
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批准号:6443847
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项目类别:
-
资助金额:$9.16万
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财政年份:2001
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负责人:Bryan R. G. Williams
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依托单位:
AFFYMETRIX MICROARRAY SYSEM
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批准号:6292234
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项目类别:
-
资助金额:$12.23万
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财政年份:2001
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负责人:Bryan R. G. Williams
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依托单位:
Mechanisms in Wilms Tumorigenesis
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批准号:6514837
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项目类别:
-
资助金额:$27.64万
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财政年份:2001
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负责人:Bryan R. G. Williams
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依托单位:
ALTERNATE PATHWAYS FOR INTERFERON AND CYTOKINE SIGNALING
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批准号:6338690
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项目类别:
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资助金额:$23.69万
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财政年份:2000
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负责人:Bryan R. G. Williams
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依托单位:
ALTERNATE PATHWAYS FOR INTERFERON AND CYTOKINE SIGNALING
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批准号:6102949
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项目类别:
-
资助金额:$23.69万
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财政年份:1999
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负责人:Bryan R. G. Williams
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依托单位:
ALTERNATE SIGNALING PATHWAYS FOR INTERFERON ALPHA
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批准号:6269631
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项目类别:
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资助金额:$23.08万
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财政年份:1998
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负责人:Bryan R. G. Williams
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依托单位:
ALTERNATE SIGNALING PATHWAYS FOR INTERFERON ALPHA
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批准号:6237443
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项目类别:
-
资助金额:$22.23万
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财政年份:1997
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负责人:Bryan R. G. Williams
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依托单位:
FUNCTION OF WILMS TUMOR GENES IN NEPHROGENESIS
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批准号:2146429
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项目类别:
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资助金额:$16.49万
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财政年份:1994
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负责人:Bryan R. G. Williams
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依托单位:
FUNCTION OF WILMS TUMOR GENES IN NEPHROGENESIS
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批准号:2146427
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项目类别:
-
资助金额:$14.02万
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财政年份:1994
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负责人:Bryan R. G. Williams
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依托单位:
FUNCTION OF WILMS TUMOR GENES IN NEPHROGENESIS
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批准号:2430212
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项目类别:
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资助金额:$17.15万
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财政年份:1994
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负责人:Bryan R. G. Williams
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依托单位:
海外基金