A synthetic vaccine against the parasitic worm Schistosoma mansoni

针对曼氏血吸虫寄生虫的合成疫苗

• 批准号: 2777630
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2777630
• 关键词: synthetic; vaccine; against; parasitic; worm

The potential of Synthetic Biology (SB) in vaccine development is under-explored. SB is applied in vaccinology in a similar fashion to other design-based approaches: computational, bioinformatic and modelling methods are used to design synthetic antigen constructs which are capable of eliciting a protective immune response. In particular, engineered scaffolds, when combined with design-based approaches, have the potential to elicit immune responses which do not occur with the natural infection. This approach promises to circumvent problems where traditional vaccines have failed- in cases where protection is short-lived or weak for example. The project therefore fits within the BBSRC remit of 'Transforming industries through bio-based processes'; in particular, it seeks to '... apply whole-cell (and enzymatic systems) and harness synthetic biology approaches, to aid the production of ... biopharmaceuticals... '

合成生物学（SB）在疫苗开发中的潜力尚未得到充分开发。SB以与其他基于设计的方法类似的方式应用于疫苗学：计算，生物信息学和建模方法用于设计能够引发保护性免疫应答的合成抗原构建体。特别是，工程支架，当与基于设计的方法相结合时，有可能引发自然感染不会发生的免疫反应。这种方法有望规避传统疫苗失败的问题--例如，在保护作用短暂或薄弱的情况下。因此，该项目符合BBSRC“通过生物工艺改造工业”的职责范围;特别是，它旨在“......应用全细胞（和酶系统）和利用合成生物学方法，以帮助生产…生物制药'