Biophysical characterisation and design of optogenetic control elements

光遗传学控制元件的生物物理表征和设计

• 批准号: 2777745
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2777745
• 关键词: Biophysical; characterisation; design; optogenetic; control

The project involves the biophysical characterisation of a recently developed optogenetic control system, based on a natural coenzyme-B12 dependent protein. It falls within the remit of 'technologies and methodological development', 'synthetic biology', and more generally 'world class bioscience' and is firmly embedded at the interface of chemistry, biology and physics, a key driver for BBSRC in the 'Exploiting new ways of working' agenda. It draws on the core bioscience skills of mathematics (data analysis), and provides advanced research training in recombinant protein production and biophysical characterisation using a range of solution spectroscopy and mass spectrometry techniques. Overall, the work will provide a highly interdisciplinary approach to (bio)chemistry/ biophysics-based research, offering highly diverse training opportunities to a PhD student. The Manchester-based supervisors have long-established collaborations with the industrial partner at the National Physical Laboratory (NPL) and the student will have the additional benefit of being able to access the local supervisors' laboratories on a daily basis, as they are co-located within the same building (MIB).

该项目涉及最近开发的光遗传控制系统的生物物理特性，该系统基于天然辅酶- b12依赖蛋白。它属于“技术和方法发展”、“合成生物学”以及更普遍的“世界级生物科学”的范畴，并牢固地嵌入化学、生物学和物理学的界面，是BBSRC“探索新的工作方式”议程的关键驱动因素。它利用数学（数据分析）的核心生物科学技能，并使用一系列溶液光谱和质谱技术提供重组蛋白生产和生物物理表征方面的高级研究培训。总的来说，这项工作将为（生物）化学/生物物理学的研究提供高度跨学科的方法，为博士生提供高度多样化的培训机会。曼彻斯特的主管与国家物理实验室（NPL）的工业合作伙伴建立了长期的合作关系，学生将获得额外的好处，即能够每天访问当地主管的实验室，因为它们位于同一栋建筑内（MIB）。