High Resolution EEG/Evoked Potential System

高分辨率脑电图/诱发电位系统

• 批准号: 7052234
• 负责人: JAMES P O'HALLORAN
• 金额: $ 55.81万
• 依托单位: NEUROCOMP SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-09 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052234
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; brain electrical activity; clinical biomedical equipment; clinical research; computer program /software; computer system design /evaluation; cost effectiveness; electrodes; electroencephalography; electronic recording system; evaluation /testing; evoked potentials; human subject

DESCRIPTION (provided by applicant): To achieve accurate localization of electrical sources of the human EEG and evoked potentials, the field on the scalp must be sampled at much higher spatial frequency than the 19 positions defined by the standard "10- 20" locations. "High resolution" (64-256 channel) EEG (hrEEG) not only provides greater localization of source generators for experimental purposes but can substantially improve diagnostic and monitoring capability for diseases such as epilepsy and stroke. Despite the availability of biopotential amplifier systems with large numbers of channels, the process of transducing the microvolt level cerebral electrical signals at the scalp surface remains difficult, requiring low and balanced contact impedances to achieve acceptable levels of line frequency (60 Hz) noise. Manual preparation of scalp sites using solvents, abrasives or syringe needles to match amplifier system input requirements is very time consuming and a major impediment to hrEEG application due to the number of channels involved. High system acquisition cost has also substantially inhibited the development and utilization of hrEEG. A low cost, preparation-free, high resolution EEG system will be developed that will entirely eliminate scalp site preparation without the use of costly on-head electronics, shielded recording environment or excessive filtering that can compromise signal integrity. Setup time for clinical and experimental protocols will be reduced to the time required for physical application of electrodes and patient irritation and risk of infection from scalp puncture during abrasion will both be eliminated. The new hrEEG system will be designed to substantially lower system cost by a new type of modular hardware architecture that achieves a highly compact form factor. An open-source software package will feature object-oriented programmability, conferring unprecedented user control and flexibility. An advanced electrode cap system will feature disposable/reusable electrodes, user-serviceability and an associated ultrasonic cleaning system that will reduce operational costs. The proposed new system will lead to increased utilization of hrEEG for experimental and clinical applications. Following first year development, the hrEEG system will be evaluated in human subjects at an independent, university-based EEG laboratory.

描述（由申请人提供）：为了实现人类脑电图和诱发电势的电源的准确定位，必须以比标准“ 10-20”位置定义的19个位置以更高的空间频率进行采样。 “高分辨率”（64-256频道）EEG（Hreeg）不仅为实验目的提供了更大的源发电机定位，而且可以大大提高癫痫和中风等疾病的诊断和监测能力。尽管有大量通道的生物电位放大器系统可用，但在头皮表面转导微伏水平的脑电信号的过程仍然很困难，需要低和平衡的接触阻抗才能达到可接受的线路频率（60 Hz）噪声。使用溶剂，磨料或注射器针对放大器系统输入要求匹配的头皮站点的手动制备非常耗时，并且由于所涉及的渠道数量而对Hreeg应用的主要障碍。高系统采集成本也大大抑制了Hreeg的发展和利用。将开发出低成本，无准备，高分辨率的脑电图系统，该系统将完全消除头皮站点的准备，而无需使用昂贵的头面电子设备，屏蔽记录环境或可能损害信号完整性的过度过滤。临床和实验方案的设置时间将减少到电极的物理应用和患者刺激以及在磨损期间感染的风险所需的时间。新的Hreeg系统将通过新型的模块化硬件体系结构来大大降低系统成本，从而实现高度紧凑的外形。开源软件包将具有面向对象的可编程性，并授予前所未有的用户控制和灵活性。先进的电极盖系统将具有一次性/可重复使用的电极，用户服务性和相关的超声清洁系统，以降低运营成本。提出的新系统将导致Hreeg在实验和临床应用中的利用率增加。在开发第一年之后，Hreeg系统将在一个基于大学的脑电图实验室的人类受试者中进行评估。