Heart Functional Assessment Using 2D Strain Rate Imaging

使用 2D 应变率成像进行心脏功能评估

• 批准号: 7098062
• 负责人: David Lambert McCubbrey
• 金额: $ 20.96万
• 依托单位: PIXEL VELOCITY, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7098062
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; computer system hardware; coronary disorder; diagnosis design /evaluation; echocardiography; heart disorder diagnosis; heart function; heart imaging /visualization /scanning; human subject; image processing; noninvasive diagnosis; phantom model

DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop a prototype system for high performance two-dimensional strain rate imaging (SRI) of the heart and assess its ability to provide noninvasive regional quantification of diastolic function. Current SRI implementations compromise image quality because simple tissue Doppler processing must be used to maintain real-time frame rates. High performance SRI with greatly reduced angle dependent artifacts requires a two-dimensional complex correlation computation at every pixel within a frame of a 200Hz ultrasound imaging sequence. In addition, simultaneous real-time display of tissue strain images and "trashograms" can provide valuable feedback information. Using these real-time displays, an echocardiographer can maximize the signal to noise ratio of SRI while simultaneously minimizing artifacts due to out-of-plane motion. Real-time computation of these images is beyond the state-of-the-art for current scanners, even those high performance machines using complex correlation for free hand, three dimensional scanning. Pixel Velocity Inc. in collaboration with the Biomedical Ultrasonics Lab at the University of Michigan, has validated the feasibility of implementing a practical real-time two-dimensional correlation processor with all these capabilities during the Phase I grant. The result of a Phase II grant will be a real-time system integrating Pixel Velocity's two-dimensional correlation processor with a WmProbe Corp. highly parallel beamformer, specifically optimized for high frame rate, two-dimensional strain rate imaging of the heart. No commercial system has the equivalent mix of beam forming and signal processing capabilities to test the clinical significance of real-time, multi-dimensional strain rate imaging.

描述（由申请人提供）：本提案的总体目标是开发一种用于心脏高性能二维应变率成像（SRI）的原型系统，并评估其提供舒张功能无创区域量化的能力。 当前的 SRI 实现会损害图像质量，因为必须使用简单的组织多普勒处理来维持实时帧速率。大幅减少角度相关伪影的高性能 SRI 需要对 200Hz 超声成像序列帧内的每个像素进行二维复杂相关计算。此外，同时实时显示组织应变图像和“垃圾图”可以提供有价值的反馈信息。使用这些实时显示，超声心动图医师可以最大限度地提高 SRI 的信噪比，同时最大限度地减少平面外运动造成的伪影。这些图像的实时计算超出了当前扫描仪的最先进水平，即使是那些使用复杂相关性进行徒手三维扫描的高性能机器也是如此。 Pixel Velocity Inc. 与密歇根大学生物医学超声实验室合作，验证了在第一阶段拨款期间实施具有所有这些功能的实用实时二维相关处理器的可行性。第二阶段资助的结果将是一个实时系统，将 Pixel Velocity 的二维相关处理器与 WmProbe Corp. 的高度并行波束形成器集成在一起，专门针对心脏的高帧率、二维应变率成像进行了优化。没有任何商业系统具有同等的波束形成和信号处理能力组合来测试实时、多维应变率成像的临床意义。