Discovery
Discovery
批准号:
7195621
负责人:
Joan Siefert Brugge
金额:
$14.59万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-08-01 至 2011-07-31
中文摘要
该倡议的总体目标是扩大目前的移徙知识库
通过使用高通量识别调节细胞形状、黏附和运动的细胞基因
RNA干扰在基于细胞或生物体的分析中进行筛选。此外,大型表情屏幕将被
在果蝇中用于识别显示表达模式和细胞内的候选基因
本地化与迁移中的角色一致。通过协调的跨物种分析,我们将确定
在细胞黏附和迁移中起中心和保守作用的一组基因。
英文摘要
The overall goal of this Initiative is to expand the current Migration Knowledgebase
through the identification of cellular genes that regulate cell shape, adhesion and motility using high throughput
RNA interference screens in cell- or organism-based assays. In addition, large scale expression screens will be
employed in the fruit fly to identify candidate genes that display patterns of expression and intracellular
localization consistent with a role in migration. Through coordinated cross-species analyses we will identify a
set of genes that play a central and conserved role in cell adhesion and migration.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Tracking the evolution of breast cancer through single cell analyses of premalignant breast tissues from women at high risk for cancer development
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批准号:10683138
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项目类别:
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资助金额:$99.67万
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财政年份:2019
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负责人:Joan Siefert Brugge
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依托单位:
Tracking the evolution of breast cancer through single cell analyses of premalignant breast tissues from women at high risk for cancer development
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批准号:10817308
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项目类别:
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资助金额:$11.45万
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财政年份:2019
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负责人:Joan Siefert Brugge
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依托单位:
Tracking the evolution of breast cancer through single cell analyses of premalignant breast tissues from women at high risk for cancer development
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批准号:10001481
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项目类别:
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资助金额:$101.7万
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财政年份:2019
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负责人:Joan Siefert Brugge
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依托单位:
Tracking the evolution of breast cancer through single cell analyses of premalignant breast tissues from women at high risk for cancer development
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批准号:10472573
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项目类别:
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资助金额:$99.67万
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财政年份:2019
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负责人:Joan Siefert Brugge
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依托单位:
Tracking the evolution of breast cancer through single cell analyses of premalignant breast tissues from women at high risk for cancer development
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批准号:10249258
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项目类别:
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资助金额:$85.16万
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财政年份:2019
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负责人:Joan Siefert Brugge
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依托单位:
Tracking the evolution of breast cancer through single cell analyses of premalignant breast tissues from women at high risk for cancer development
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批准号:9816264
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项目类别:
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资助金额:$101.7万
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财政年份:2019
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负责人:Joan Siefert Brugge
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依托单位:
Breast Tumor Heterogeneity and its Impact on Tumor Progression
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批准号:8633707
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项目类别:
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资助金额:$34.77万
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财政年份:2014
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负责人:Joan Siefert Brugge
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依托单位:
Analysis of Intratumoral Crosstalk in Clonal Populations of OvarianTumor Cells
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批准号:8839745
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项目类别:
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资助金额:$39.79万
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财政年份:2014
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负责人:Joan Siefert Brugge
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依托单位:
Analysis of Intratumoral Crosstalk in Clonal Populations of OvarianTumor Cells
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批准号:8613292
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项目类别:
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资助金额:$39.82万
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财政年份:2014
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负责人:Joan Siefert Brugge
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依托单位:
Analysis of Intratumoral Crosstalk in Clonal Populations of OvarianTumor Cells
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批准号:9025763
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项目类别:
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资助金额:$39.65万
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财政年份:2014
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负责人:Joan Siefert Brugge
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依托单位:
Use of Organotypic and Mammary Gland Models to Investigate the Outcomes of Clonal
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批准号:8215975
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项目类别:
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资助金额:$36.85万
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财政年份:2011
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负责人:Joan Siefert Brugge
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依托单位:
Use of Organotypic and Mammary Gland Models to Investigate the Outcomes of Clonal
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批准号:7617421
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项目类别:
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资助金额:$38.44万
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财政年份:2009
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负责人:Joan Siefert Brugge
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依托单位:
Variation in Receptor Tyrosine Kinases and Breast Cancer Risk
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批准号:7729488
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项目类别:
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资助金额:$16.96万
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财政年份:2008
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负责人:Joan Siefert Brugge
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依托单位:
P-6: Variation in Receptor Tyrosine Kinases and Breast Cancer Risk
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批准号:6966199
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项目类别:
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资助金额:$10.65万
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财政年份:2005
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负责人:Joan Siefert Brugge
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依托单位:
Mechanisms Involved in Mammary Morphogenesis
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批准号:6989354
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项目类别:
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资助金额:$14.87万
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财政年份:2004
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负责人:Joan Siefert Brugge
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依托单位:
Cell Death Regulation in Lumen Formation and Oncogenesis
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批准号:7368284
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项目类别:
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资助金额:$48.17万
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财政年份:2003
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负责人:Joan Siefert Brugge
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依托单位:
Cell Death Regulation in Lumen Formation and Oncogenesis
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批准号:7895915
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项目类别:
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资助金额:$51.26万
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财政年份:2003
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负责人:Joan Siefert Brugge
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依托单位:
Cell Death Regulation in Lumen Formation and Oncogenesis
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批准号:6719923
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项目类别:
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资助金额:$37.44万
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财政年份:2003
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负责人:Joan Siefert Brugge
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依托单位:
Cell Death Regulation in Lumen Formation and Oncogenesis
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批准号:6933879
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项目类别:
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资助金额:$37.71万
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财政年份:2003
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负责人:Joan Siefert Brugge
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依托单位:
Cell Death Regulation in Lumen Formation and Oncogenesis
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批准号:7104444
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项目类别:
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资助金额:$36.83万
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财政年份:2003
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负责人:Joan Siefert Brugge
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依托单位:
海外基金