Investigating the role of uterine macrophages during the menstrual cycle and early pregnancy

研究子宫巨噬细胞在月经周期和妊娠早期的作用

• 批准号: 2781794
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2781794
• 关键词: Investigating; role; uterine; macrophages; during

The human endometrium (uterus lining) is a highly regenerative tissue which undergoes dynamic changes throughout the menstrual cycle, embryo implantation and early pregnancy. Facilitating these transformations requires complex crosstalk between structural cell populations such as stromal, epithelial and endothelial cells, and immune cells populations. Macrophages are innate immune cells that play important and dynamic roles during reproductive cycles and early pregnancy in mouse models, however our understanding in humans is relatively poor in comparison. The aim of this project is to elucidate these complex interactions between macrophages and resident structural cells in the human uterus, and to reveal how these interactions facilitate tissue remodelling, embryo implantation and pregnancy progression to maintain reproductive health and prevent poor pregnancy outcomes.

人类子宫内膜（子宫内膜）是一种高度再生的组织，在整个月经周期、胚胎植入和妊娠早期经历动态变化。促进这些转化需要结构细胞群（例如基质细胞、上皮细胞和内皮细胞）与免疫细胞群之间的复杂串扰。巨噬细胞是先天免疫细胞，在小鼠模型的生殖周期和妊娠早期发挥着重要和动态的作用，但相比之下，我们对人类的了解相对较差。该项目的目的是阐明巨噬细胞和人类子宫中常驻结构细胞之间的复杂相互作用，并揭示这些相互作用如何促进组织重塑、胚胎植入和妊娠进展，以维持生殖健康并防止不良妊娠结局。