Microrheology of Dense DNA solutions

致密 DNA 溶液的微观流变学

• 批准号: 2782482
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2782482
• 关键词: Microrheology; Dense; DNA; solutions

The interplay between the microstructure and the rheological response of a material is one of the central areas of investigation in the realm of soft matter physics. The entanglement dynamics of ring polymers, in particular, still present a challenging puzzle. DNA being an ubiquitous polymer, is an excellent system for investigating fundamental questions in polymer physics because of its exceptional monodispersity and multiple naturally occurring topologies. At high concentrations, DNA strands form a dynamic, transient network due to topological constraints preventing DNA molecules from crossing each other, reminiscent of entanglements observed in dense polymer solutions. This project aims to investigate the viscoelastic properties of dense DNA solutions, focusing on ring DNA, using particle tracking microrheology.

材料的微观结构和流变响应之间的相互作用是软物质物理领域研究的中心领域之一。特别是环状聚合物的纠缠动力学，仍然是一个具有挑战性的难题。DNA是一种普遍存在的聚合物，由于其独特的单分散性和多种自然发生的拓扑结构，是研究聚合物物理基本问题的绝佳系统。在高浓度下，由于拓扑限制，DNA链形成一个动态的瞬时网络，阻止DNA分子相互交叉，让人想起在致密聚合物溶液中观察到的缠结。本项目旨在研究密集DNA溶液的粘弹性特性，重点是环DNA，使用颗粒跟踪微流变学。