SNRP Project at Meharry Medical College

梅哈里医学院的 SNRP 项目

• 批准号: 7087237
• 负责人: Hubert K. Rucker
• 金额: $ 125.65万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7087237
• 关键词: cooperative study; minority institution research support; neurosciences; science education

DESCRIPTION (provided by applicant) The long-range vision for neuroscience research at Meharry Medical College (MMC) is to achieve excellence in brain and behavioral research from bench to bedside, synergistically engaging institutional resources and extramural funding for research and training to achieve this important goal. This Specialized Neuroscience Research Program (SNRP) competing continuation application is essential to provide resources to continue to enhance the research and training environment at MMC, in partnership with Vanderbilt University Medical Center (VUMC). To that end, this proposal describes three research programs related to the overall theme of brain plasticity, broadly defined, that address important biological problems in the context of nurturing collaborations that will facilitate the development of research and research communication skills, ultimately leading to individual peer-reviewed funding for these three junior MMC faculty. The proposed research of Dr T. Ansah addresses the possible role of the 5HT-2A/C receptor in effecting cortical control of movement in Parkinson's disease, when the reciprocal dopaminergic regulatory inputs have been ablated by this degenerative disease (VUMC collaborator: Dr. Ariel Deutch). The studies of Dr W. Fan explore whether desensitization of chemokine regulation of neurons (or supporting tissues) in the CMS contributes to the development of Alzheimer's disease pathology, and - if so- whether interference with enhanced chemokine receptor expression and/or activation will.permit a novel axis for therapeutic intervention (VUMC collaborator: Ann Richmond). Dr. Mitchell Parks will examine the plasticity of brain development by examining the impact of childhood sexual abuse on the choice-behavior wiring (dubbed executive function) in adult survivors of this abuse, examining both African American and Caucasian females, and correlating clinical and behavioral analyses with objective imaging parameters obtained using fMRI (MMC psychologist & Collaborator: Fred Ernst; VUMC imaging scientist & Collaborator: Malcolm Avison). Frequent meetings between the collaborators and among the SNRP investigative teams overall will be complemented with journal clubs, seminar series, works in progress sessions, and input from external advisors to provide significant constructive input concerning hypothesis testing, experimental design, testing of alternative interpretations of data, and communicating these findings in oral and written form to achieve the individual success of these investigators and to strengthen the portfolio of bench to bedside neuroscience research at MMC and with its Alliance partner, VUMC

描述（由申请人提供） 在梅哈里医学院（MMC）神经科学研究的长期愿景是实现卓越的大脑和行为研究从板凳到床边，协同参与机构资源和研究和培训的校外资金，以实现这一重要目标。这个专业神经科学研究计划（SNRP）竞争继续应用程序是必不可少的，以提供资源，继续加强研究和培训环境在MMC，与范德比尔特大学医学中心（VUMC）合作。为此，该提案描述了与大脑可塑性的总体主题相关的三个研究项目，广泛定义，在培养合作的背景下解决重要的生物学问题，这将促进研究和研究沟通技能的发展，最终导致这三个初级MMC教师的个人同行评审资金。T博士提出的研究。Ansah阐述了5 HT-2A/C受体在帕金森病中影响皮质运动控制的可能作用，当这种退行性疾病消除了相互的多巴胺能调节输入时（VUMC合作者：Ariel Deutch博士）。W. Fan研究了CMS中神经元（或支持组织）的趋化因子调节的脱敏是否有助于阿尔茨海默病病理学的发展，以及-如果是-干扰增强的趋化因子受体表达和/或活化是否将允许治疗干预的新轴（VUMC合作者：Ann里士满）。米切尔·帕克斯博士将通过研究儿童期性虐待对选择行为线路的影响来研究大脑发育的可塑性（被称为执行功能），检查非洲裔美国人和白人女性，并将临床和行为分析与使用fMRI获得的客观成像参数相关联（MMC心理学家和合作者：Fred Ernst; VUMC成像科学家和合作者：Malcolm Avison）。合作者之间和SNRP调查团队之间的频繁会议将通过期刊俱乐部，研讨会系列，正在进行的工作会议以及外部顾问的投入来补充，以提供有关假设检验，实验设计，数据替代解释测试的重要建设性投入，并以口头和书面形式传达这些发现，以实现这些研究者的个人成功，并加强MMC的临床神经科学研究组合，其联盟合作伙伴VUMC