Expiratory muscle training in patients with Parkinson's

这个项目测试了一种新的训练方法的结果，以加强呼吸系统的肌肉。针对呼气肌，这项技术被称为呼气肌力量训练（EMST）。EMST为用户提供了一个实验性高压阈值装置，在呼吸过程中对肌肉施加高生理负荷。治疗持续4周，大部分训练在患者家中进行。我们打算在一组特发性帕金森病（IPD）患者中测试EMST的结果。帕金森氏症是一种使人衰弱的疾病，对呼吸、咳嗽、吞咽和语言等运动功能有众所周知的不良影响。本研究的一般目的是首先确定具有特定IPD严重程度的患者是否可以改善呼气肌力，其次确定呼气肌力的改善会影响哪些结果变量。我们预期在治疗后呼吸、咳嗽、吞咽和语言的改善可归因于训练技术。对三组30名患有Hoehn & Yahr， I-III期IPD的受试者进行研究，分为治疗组、假组和对照组，以确定该技术的治疗效果。定量测量包括测量音量、流量、声压级和视频指数，以及听众感知测试，以确定该技术对整体音质和语音清晰度的影响。该项目的结果将为EMST项目作为一种新技术提供新的信息。奖助金的目标符合R21的使命。由于治疗方案的创新性和作为一种治疗方法的潜在成本效益，其潜在影响是很高的。

This project tests the outcome of a novel training method for strengthening the muscles of the respiratory system. Targeting the expiratory muscles, the technique is referred to as expiratory muscle strength training (EMST). EMST provides the user with an experimental high-pressure threshold device which places a high physiological load on the muscles during breathing. The treatment lasts 4 weeks and the majority of the training takes place in the person's home. We intend to test the outcome of EMST in a group of individuals with idiopathic Parkinson disease (IPD). Parkinson's disease is a debilitating disease with well-recognized adverse effects on motor function including breathing, cough, swallow and speech. The general purpose of this research is to first determine if those with a specific severity of IPD can improve expiratory muscle strength and secondly to determine what outcome variables are affected by the improvements in expiratory muscle strength. We anticipate improvements in breathing, cough, swallow and speech following treatment that are attributable to the training technique. Study of three groups of 30 subjects with Hoehn & Yahr, stage I-III IPD in a treatment, sham and control group will define the therapeutic effect of this technique. Quantitative measures include measures of volume, flow, sound pressure level and videoflourographic indices as well as listener perception tests to determine the technique's impact on overall sound quality and speech intelligibility. Results from this project will provide new information about the EMST program as a novel technique. The goals of the grant meet the mission of the R21. Its potential impact is high due to the therapy program's innovative nature and potential cost-effectiveness as a treatment approach.