Functions of viral chemokine receptor homologues important for cytomegalovirus pathogenesis and latency

病毒趋化因子受体同源物的功能对巨细胞病毒发病机制和潜伏期很重要

• 批准号: nhmrc : 631401
• 负责人: A/Pr Nicholas Davis-Poynter
• 金额: $ 30.78万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functions-viral-chemokine-pathogenesis-latency/81639
• 关键词: Functions; viral; chemokine; receptor; homologues

Cytomegalovirus (CMV) causes life-threatening disease in babies, transplant recipients and HIV-AIDS patients. We will focus on a CMV gene that has been 'hijacked' from the host cell and enables the virus to switch on signalling molecules within infected cells. We will determine how these signals enable CMV to infect sites of the body that are critical for virus transmission and contribute to long-term virus persistence. Our results will provide new strategies for drugs against CMV.

巨细胞病毒（CMV）可导致婴儿、移植受者和艾滋病毒/艾滋病患者发生危及生命的疾病。我们将重点关注CMV基因，该基因已从宿主细胞中被“劫持”，并使病毒能够在感染细胞内打开信号分子。我们将确定这些信号如何使CMV感染对病毒传播至关重要的身体部位，并有助于病毒的长期持续存在。我们的研究结果将为抗CMV药物提供新的策略。