G-proteins and transmembrane signalling

G 蛋白和跨膜信号传导

• 批准号: nhmrc : 142000
• 负责人: Dr Siiri Iismaa
• 金额: $ 30.24万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/g-proteins-transmembrane-signalling/97968
• 关键词: proteins; transmembrane; signalling

The co-ordinated regulation of cellular functions by hormones is vital to be able to respond to both immediate and long-term environmental changes and stresses. The stress hormone, adrenaline, affects in particular, the cardiovascular system, causing constriction of small arteries and increases in the force and rate of contraction of the heart, by binding to, and activating, adrenergic receptor proteins present on the cell surface. Activation of these receptors is implicated in the development of cardiac hypertrophy, as well as ventricular arrhthymias following ischaemia and reperfusion. Understanding the precise mechanisms or pathways of activation of these receptors is, therefore, of direct relevance to the treatment of these important clinical disorders. We have recently discovered a new protein, Gh, involved in the regulation of cellular functions by adrenergic receptors. The aims of this proposal are to determine the importance of Gh in the heart and understand the molecular mechanisms that control the function of this protein. Such insights are of paramount importance as they have direct applicability to our understanding of the heart s response to stress and may lead to new diagnostic or therapeutic approaches for the treatment of cardiac diseases.

激素对细胞功能的协调调节对于能够应对即时和长期的环境变化和压力至关重要。应激激素肾上腺素特别影响心血管系统，通过结合并激活细胞表面上的肾上腺素能受体蛋白，引起小动脉收缩并增加心脏收缩的力和速率。这些受体的激活与心肌肥大的发展以及缺血和再灌注后的心室心律失常有关。因此，了解这些受体激活的确切机制或途径与这些重要临床疾病的治疗直接相关。我们最近发现了一种新的蛋白质，Gh，参与肾上腺素能受体对细胞功能的调节。该提案的目的是确定Gh在心脏中的重要性，并了解控制这种蛋白质功能的分子机制。这些见解至关重要，因为它们直接适用于我们对心脏对压力的反应的理解，并可能导致治疗心脏疾病的新诊断或治疗方法。