Device for Promoting Survival of Congested Tissue Flaps

促进充血组织瓣存活的装置

• 批准号: 6874494
• 负责人: JOHN A. RUSSELL
• 金额: $ 40.65万
• 依托单位: SPECTROCON, LLC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6874494
• 关键词: autotransfusion; biomedical automation; biomedical equipment development; biotechnology; blood coagulation; histology; laboratory rat; miniature biomedical equipment; oxygen tension; surgery material /equipment; swine; vein occlusion

DESCRIPTION (provided by applicant): New technology is needed for the treatment of venous congestion, a serious complication of reconstructive surgery. Currently, live leeches are used, but are psychologically traumatic to patients, and are often ineffective in preventing tissue death. Because there are no other alternatives for treating venous congestion, a mechanical device for this purpose represents an innovative concept. The long-term goal of this research is to develop AutoFIow, a fully automated medical device for treating venous congestion. In Phase I, we demonstrated the feasibility of developing and using AutoFIow in a pig model. In Phase II, our aims are: (1) to miniaturize AutoFIow, (2) to reduce the number of bleeding sites required for AutoFIow treatment by increasing bleeding time per applied wound; methods of treating endothelial and interstitial edema will be incorporated for this purpose, and (3) to incorporate blood autotransfusion capability. Crucial refinements in size will expand the use of AutoFIow to tissue configurations not currently supported by our prototype, such as fingers, and to potential use in children. Miniaturization and increased bleeding time per wound will result in decreased potential for tissue damage. By incorporating methods of returning autologous blood to the patient, the blood transfusions frequently required by live leech therapy will be eliminated. Miniaturization, longer wound bleeding times, and autotransfusion will create a large functional divide between use of AutoFIow and medicinal leeches, and will establish AutoFlow as the universally preferred method for the treatment for venous congestion in the marketplace.

描述（由申请人提供）： 静脉充血是重建手术的严重并发症，需要新的技术来治疗。目前，使用活水蛭，但对患者造成心理创伤，并且通常在防止组织死亡方面无效。由于没有其他治疗静脉充血的替代方案，因此用于此目的的机械装置代表了一种创新概念。这项研究的长期目标是开发AutoFIow，这是一种用于治疗静脉充血的全自动医疗设备。在第一阶段，我们证明了在猪模型中开发和使用AutoFIow的可行性。在II期研究中，我们的目标是：（1）实现AutoFIow，（2）通过增加每个应用伤口的出血时间来减少AutoFIow治疗所需的出血部位数量;为此目的，将纳入治疗内皮和间质性水肿的方法，以及（3）纳入自体输血能力。尺寸的关键改进将扩大AutoFIow的使用范围，使其适用于我们的原型目前不支持的组织配置，如手指，以及儿童的潜在用途。每个伤口的小型化和出血时间增加将导致组织损伤的可能性降低。通过将自体血液返回到患者体内的方法，将消除活水蛭治疗经常需要的输血。微型化、伤口出血时间更长和自体输血将在AutoFlow和医用水蛭的使用之间产生巨大的功能差异，并将使AutoFlow成为市场上治疗静脉充血的普遍首选方法。