Integrating Nano-devices with Microfluidic Systems

纳米器件为数字医疗应用提供高分辨率生物检测。在这方面，床旁（POC）设备在人类疾病的快速诊断、预防和治疗中具有关键作用。结合是生物传感器性能的关键因素。为了获得良好的性能的生物传感器，一个需要检查的生物分子与传感器的相互作用。将生物分子转移到传感平台是将纳米结构用于生物传感目的的根本挑战。本计画旨在建立一个新的平台，以了解微流控整合生物感测器中的物质传输与结合动力学过程。这包括对单个生物分子检测的全面流动行为分析，然后是将各种物种系统结合到预定义的纳米传感器中的动力学模型。该项目将有广泛的应用，从药物发现到医学诊断，到食品安全，再到农业和环境监测。因此，该项目的目的是开发新的数学和计算工具，用于分析生物传感器中的结合动力学，重点是协助下一代技术进行快速有效的诊断，这与EPSRC医疗保健技术主题相一致。该项目将支持Eluceda商业化的传感器技术的开发和优化，用于生物，化学和体外诊断应用。

Nanodevices enable high resolution bio-detections for digital healthcare applications. In this respect, point-of-care (POC) devices have a critical role in rapid diagnosis, prevention and treatment of human diseases. Binding is a key factor in the biosensor performance. To achieve a good performance of biosensors, one needs to examine the biomolecular interactions with sensors. Transferring bio-molecules into the sensing platform is the fundamental challenge to use nanostructures for biosensing purposes. This project aims to introduce a novel platform to understand the mass transport and binding kinetic process in microfluidic integrated biosensors. This includes a comprehensive flow behaviour analysis for a single bio-molecule detection followed by a systemic binding kinetic model of various species into pre-defined nanosensors. This project will have a wide range of applications from drug discovery to medical diagnostics, to food safety, to agricultural and environmental monitoring. The purpose of this project, therefore, is to develop new mathematical and computation tools for analysing binding kinetics in biosensors, with a focus on assisting next generation technologies for rapid and effective diagnosis, which is aligned with the EPSRC Healthcare Technologies theme. The proposed project will support the development and optimisation of sensor technologies commercialised by Eluceda for biological, chemical, and in vitro diagnostic applications.