Integrating Nano-devices with Microfluidic Systems

纳米设备使数字医疗保健应用的高分辨率生物检测成为可能。在这方面，医疗点(POC)设备在人类疾病的快速诊断、预防和治疗中发挥着至关重要的作用。结合作用是影响生物传感器性能的关键因素。为了实现生物传感器的良好性能，需要研究生物分子与传感器之间的相互作用。将生物分子转移到传感平台是将纳米结构用于生物传感的根本挑战。本项目旨在介绍一个新的平台，以了解微流控集成生物传感器中的质量传输和结合动力学过程。这包括对单个生物分子检测的全面流动行为分析，然后是各种物种到预定义纳米传感器的系统结合动力学模型。该项目将有广泛的应用，从药物发现到医疗诊断，到食品安全，再到农业和环境监测。因此，该项目的目的是开发新的数学和计算工具，用于分析生物传感器中的结合动力学，重点是协助下一代技术进行快速和有效的诊断，这与EPSRC医疗保健技术主题保持一致。拟议的项目将支持Eluceda为生物、化学和体外诊断应用商业化的传感器技术的开发和优化。

Nanodevices enable high resolution bio-detections for digital healthcare applications. In this respect, point-of-care (POC) devices have a critical role in rapid diagnosis, prevention and treatment of human diseases. Binding is a key factor in the biosensor performance. To achieve a good performance of biosensors, one needs to examine the biomolecular interactions with sensors. Transferring bio-molecules into the sensing platform is the fundamental challenge to use nanostructures for biosensing purposes. This project aims to introduce a novel platform to understand the mass transport and binding kinetic process in microfluidic integrated biosensors. This includes a comprehensive flow behaviour analysis for a single bio-molecule detection followed by a systemic binding kinetic model of various species into pre-defined nanosensors. This project will have a wide range of applications from drug discovery to medical diagnostics, to food safety, to agricultural and environmental monitoring. The purpose of this project, therefore, is to develop new mathematical and computation tools for analysing binding kinetics in biosensors, with a focus on assisting next generation technologies for rapid and effective diagnosis, which is aligned with the EPSRC Healthcare Technologies theme. The proposed project will support the development and optimisation of sensor technologies commercialised by Eluceda for biological, chemical, and in vitro diagnostic applications.