Bioengineering Sustainable Microgel Particles and Multiscale Characterization of Material Properties

生物工程可持续微凝胶颗粒和材料特性的多尺度表征

• 批准号: 2826717
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2826717
• 关键词: Bioengineering; Sustainable; Microgel; Particles; Multiscale

Microgel particles are deformable functional soft materials made by crosslinking polymers in a solvent with sizes of these particles ranging from hundreds of nanometers to several micrometers. Microgels have a wide range of industrial applications, such as emulsion and foam stabilization, drug delivery, biosensing and they also serve as lubricants, switchable materials, diagnostics, viscosity modifiers, cell substrates etc. Although advances in synthesis, experimental and simulation methodologies have clarified design principles and put microgels at the forefront of soft matter research, little focus has been placed in designing sustainable microgels using plant-based materials. Designing microgels with plant proteins is challenging because of their poor aqueous solubility arising from the complex quaternary structure, and their strong tendency for self-aggregation and association with other metabolites such as polyphenols in the natural state. In this interdisciplinary PhD project involving academics from Food Colloids, Nutrition, Biophysics, Theoretical Physics and Collaborators from Oatly, we aim to design new plant-based sustainable microgel and create new fundamental understanding of the relationship between structural features and mechanical properties relevant to industrial processing as well as oral processing in the mouth. The student will create novel sustainable microgels using oat protein polysaccharides and ions using an array of biotechnological and physical approaches. In addition to experimental work on structure-property relationship at macro-to-nanoscale combining multiple techniques (e.g. light scattering, SAXS, SANS, confocal and electron microscopy imaging, rheology, tribology, Rheo-SANS), coarse grain modelling of microgels at single particle level as well as microgel-microgel interaction levels will be carried out to provide a predictive theoretical indication of bulk properties. There will be also an interesting opportunity for the student to also do a placement at Sweden in the R&D facility.

微凝胶颗粒是由聚合物在溶剂中交联而成的可变形的功能软材料，这些颗粒的尺寸从数百纳米到几微米不等。微凝胶具有广泛的工业应用，例如乳液和泡沫稳定、药物递送、生物传感，并且它们还用作润滑剂、可转换材料、诊断、粘度调节剂、细胞基质等。虽然合成、实验和模拟方法学的进步已经阐明了设计原理，并将微凝胶置于软物质研究的最前沿，很少关注使用植物基材料设计可持续的微凝胶。设计具有植物蛋白质的微凝胶是具有挑战性的，因为它们的水溶性差，由复杂的四级结构，以及它们的自聚集和与其他代谢物如多酚在自然状态下的关联的强烈倾向。在这个跨学科的博士项目中，涉及来自食品胶体，营养学，生物物理学，理论物理学和Oatly合作者的学者，我们的目标是设计新的植物基可持续微凝胶，并对结构特征和机械性能之间的关系建立新的基本理解与工业加工以及口腔加工有关。学生将使用燕麦蛋白多糖和离子，使用一系列生物技术和物理方法，创造新的可持续微凝胶。除了结合多种技术（例如光散射，SAXS，SANS，共聚焦和电子显微镜成像，流变学，摩擦学，Rheo-SANS）在宏观到纳米级的结构-性能关系的实验工作外，还将进行单颗粒水平以及微凝胶-微凝胶相互作用水平的微凝胶粗粒建模，以提供本体性能的预测性理论指标。也将有一个有趣的机会，让学生也做一个在瑞典的R&D设施的安置。