MODULATION OF CHIMERISM FOR INTESTINAL TRANSPLANTATION

描述（由申请人提供）：本提案的目的是支持西南国家灵长类动物研究中心（SNPRC）的持续发展。SNPRC位于其主办机构西南生物医学研究基金会的校园内。SNPRC饲养了超过6，000种非人灵长类动物，包括狒狒、恒河猴、食蟹猴、黑猩猩、绒猴、绢毛猴、长尾猴、蜘蛛猴和猪尾猴。我们维持狒狒、恒河猴、食蟹猴和绒猴的大量繁殖种群。我们的动物资源包括世界上最大的狒狒圈养种群，世界上最大的非人灵长类动物种群，以及不断增长的SPF印度恒河猴种群。在目前的赠款期间，SNPRC向来自27个州的267名调查人员提供了资源。SNPRC分为五种类型的组件：行政，培训和推广，灵长类动物殖民地，资源和资源相关的研究组件。这些组成部分分为三个组：比较医学，病毒学和免疫学，遗传学组。现有资源包括临床和解剖病理学;兽医技术服务;生物材料收集和分发;血液、组织和DNA储存库;黑猩猩肝炎监测;逆转录病毒诊断;流式细胞术;分子遗传学服务。建议开发的其他资源包括行为服务、托儿所、灵长类动物基因组学数据库、阵列技术和内皮细胞 技术.还提出了开发和加强非人灵长类动物模型的组成部分，用于研究肝炎、结核病、恰加斯病、线虫感染、糖尿病和心血管疾病。

Description (provided by applicant):The objective of this proposal is to support the continuing development of the Southwest National Primate Research Center (SNPRC). The SNPRC is located on the campus of the Southwest Foundation for Biomedical Research, its host institution. The SNPRC maintains over 6,000 nonhuman primates including baboons, rhesus macaques, cynomolgus macaques, chimpanzees, marmosets, tamarins, vervet monkeys, spider monkeys, and pigtail macaques. We maintain large breeding populations of baboons, rhesus macaques, cynomolgus macaques and marmosets. Our animal resources include the largest captive population of baboons anywhere in the world, the largest pedigreed population of any nonhuman primate species in the world, and a growing population of SPF Indian-origin rhesus macaques. During the current grant period, the SNPRC provided resources to 267 investigators from 27 states. The SNPRC is divided into five types of components: Administrative, Training and Outreach, Primate Colonies, Resource, and Resource-related Research components. These components are organized within three groups: Comparative Medicine, Virology and Immunology, and Genetics Group. Ongoing resource components include clinical and anatomic pathology; veterinary technical services; biomaterials collection and distribution; a blood, tissue and DNA repository; chimpanzee hepatitis surveillance; retrovirus diagnostics; flow cytometry; and molecular genetics services. Additional resources proposed for development include behavioral services; the nursery; a primate genomics database; array technologies; and endothelial cell technologies. Components also are proposed to develop and enhance nonhuman primate models for research on hepatitis, tuberculosis, Chagas' Disease, nematode infection, diabetes and cardiovascular disease.