REGULATION OF THE DUCTUS ARTERIOSIS

动脉导管的调节

• 批准号: 7165308
• 负责人: RONALD I CLYMAN
• 金额: $ 3.05万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7165308
• 关键词: Primates; animal colony

Description (provided by applicant):The objective of this proposal is to support the continuing development of the Southwest National Primate Research Center (SNPRC). The SNPRC is located on the campus of the Southwest Foundation for Biomedical Research, its host institution. The SNPRC maintains over 6,000 nonhuman primates including baboons, rhesus macaques, cynomolgus macaques, chimpanzees, marmosets, tamarins, vervet monkeys, spider monkeys, and pigtail macaques. We maintain large breeding populations of baboons, rhesus macaques, cynomolgus macaques and marmosets. Our animal resources include the largest captive population of baboons anywhere in the world, the largest pedigreed population of any nonhuman primate species in the world, and a growing population of SPF Indian-origin rhesus macaques. During the current grant period, the SNPRC provided resources to 267 investigators from 27 states. The SNPRC is divided into five types of components: Administrative, Training and Outreach, Primate Colonies, Resource, and Resource-related Research components. These components are organized within three groups: Comparative Medicine, Virology and Immunology, and Genetics Group. Ongoing resource components include clinical and anatomic pathology; veterinary technical services; biomaterials collection and distribution; a blood, tissue and DNA repository; chimpanzee hepatitis surveillance; retrovirus diagnostics; flow cytometry; and molecular genetics services. Additional resources proposed for development include behavioral services; the nursery; a primate genomics database; array technologies; and endothelial cell technologies. Components also are proposed to develop and enhance nonhuman primate models for research on hepatitis, tuberculosis, Chagas' Disease, nematode infection, diabetes and cardiovascular disease.

描述(申请人提供)：本提案旨在支持西南国家灵长类动物研究中心(SNPRC)的持续发展。SNPRC位于其主办机构西南生物医学研究基金会的校园内。SNPRC饲养着6000多种非人类灵长类动物，包括狒狒、恒河猴、食蟹猴、黑猩猩、绒猴、罗望子、马尾猴、蜘蛛猴和辫子猕猴。我们维持着大量的狒狒、恒河猴、食蟹猴和绒猴的繁育种群。我们的动物资源包括世界上最大的圈养狒狒种群，世界上所有非人类灵长类物种中最大的纯种种群，以及不断增长的SPF印度血统恒河猴种群。在目前的赠款期间，SNPRC向来自27个州的267名调查人员提供了资源。SNPRC分为五种类型的组成部分：行政、培训和外联、灵长类群体、资源和与资源相关的研究组成部分。这些组成部分分为三个组：比较医学、病毒学和免疫学以及遗传学组。目前的资源部分包括临床和解剖病理学；兽医技术服务；生物材料的收集和分发；血液、组织和DNA储存库；黑猩猩肝炎监测；逆转录病毒诊断；流式细胞术；以及分子遗传学服务。建议开发的其他资源包括行为服务、托儿所、灵长类基因组数据库、阵列技术和内皮细胞。 技术。还建议开发和增强用于研究肝炎、结核病、恰加斯病、线虫感染、糖尿病和心血管疾病的非人类灵长类动物模型的组件。