EVALUATION OF INHIBITION OF SHIV REPLICATION BY SIRNA VECTORS

描述（由申请人提供）： 这一更新申请要求为NENPRC的多学科生物医学研究和资源计划的继续提供五年的资金。 研究人员将继续追求美国国立卫生研究院（NIH）指导的使命，即利用非人灵长类动物（NHP）的独特特征进行有价值的研究，有助于理解和解决人类健康疾病。 为了进一步实现这一目标，应用程序的重点是为七个科学核心提供支持（行为生物学、比较病理学、免疫学、微生物学、神经化学、灵长类动物资源和肿瘤病毒学）;进行试点研究;并提供中心范围内的支持服务，重点是传染病的发病机制，艾滋病的治疗和预防，基础免疫学，疱疹病毒的致癌性，神经退行性疾病和药物成瘾。 此外，该提案旨在：1）通过提供专业设施、设备和技术专长，提高中心作为合作、附属和访问科学家的区域、国家和国际资源的能力; 2）提高NHP在生物医学研究中的可用性; 3）培训年轻的研究人员;以及4）提供维持和运营中心所需的行政、科学和灵长类动物资源基础设施。 四个殖民地健康相关的资源项目也包括在这个应用程序以及一个五年的改进和现代化计划。 NENPRC，HMS获得美国实验动物管理认证协会（AAALAC）国际的完全认证。

DESCRIPTION (provided by applicant): This renewal application requests five years of funding for the continuation of the NENPRC's multidisciplinary biomedical research and resource program. The investigators will continue to pursue the National Institutes of Health (NIH) directed mission of utilizing the unique characteristics of nonhuman primates (NHPs) to conduct meritorious research that contributes to the understanding and solution of human health diseases. To further this objective, the emphasis of the application is to provide support for seven science cores (Behavioral Biology, Comparative Pathology, Immunology, Microbiology, Neurochemistry, Primate Resources, and Tumor Virology); to conduct pilot research; and provide Center-wide support services with emphasis on the pathogenesis of infectious diseases, treatment and prophylaxis of AIDS, basic immunology, ongenicity of herpesvirus, neurodegenerative diseases, and drug addiction. Additionally, this proposal seeks to: 1) enhance the Center's ability to serve as a regional, national, and international resource for collaborative, affiliate, and visiting scientists by providing specialized facilities, equipment, and technological expertise; 2) enhance the availability of NHPs for use in biomedical research; 3) train young investigators; and 4) provide the administrative, scientific, and primate resources infrastructure necessary to maintain and operate a Center. Four colony health-related resource projects are also included in this application as well as a five year Improvement and Modernization Program. The NENPRC, HMS, is fully accredited by the American Association for the Accreditation of Laboratory Animal Care (AAALAC) International.