STRUCTURAL AND FUNCTIONAL FEATURES OF THE 5-HT3R BINDING SITE

描述（由申请人提供）：阿拉斯加INBRE建议建立一个网络，将扩大和加强我们在生物医学研究的能力和性能，重点是增加R 01资金。我们还提出了有效的教学策略和研究机会，为整个国家的本科生，以发展教育管道。具体目标是：1）扩大和维持环境卫生研究的校园间网络，继续关注生存物种的分子毒理学和传染病病原体的新兴焦点，包括人畜共患病; 2）支持INBRE初级教师，博士后和研究生的研究项目; 3）为本科生提供研究机会，从新生到毕业的大四学生，横跨阿拉斯加; 4）接触阿拉斯加较小的学院，卫生公司，医院和农村地区其他组织的学生和教师，目的是让他们参与INBRE研究项目; 5）通过培训计划和过渡到网络校园的大学课程，提高阿拉斯加劳动力的科学知识 和外联网站。七个最近的UA教师招聘形成的研究主题的智力骨干，在INBRE提出了两个新的教师职位。大量资金的目标是为这些年轻的教师提供研究项目支持（试点项目赠款），以及指导，研究生支持和其他教师培训和发展机会。生物信息学核心教师为研究人员的研究核心团队提供研究方法和数据管理方面的专业知识。INBRE外展核心计划将开发和扩大本科生管道到健康职业和生物医学研究生教育，并包括支持本科生研究实习，新的生物医学课程工作，以及专门针对阿拉斯加原住民学生的辅导计划。

DESCRIPTION (provided by applicant): Alaska INBRE proposes to build a Network that will broaden and strengthen our capacity and performance in biomedical research, with an emphasis on increased R01 funding. We also propose effective teaching strategies and research opportunities for undergraduate students throughout the state in order to grow an educational pipeline. The Specific Aims are: 1) To enlarge and sustain the inter-campus network for environmental health research with a continuing focus on molecular toxicology of subsistence species and an emerging focus on infectious agents, including zoonotic diseases; 2) To support research projects of INBRE junior faculty, postdocs, and graduate students; 3) To provide research opportunities for undergraduate students, from rising freshmen to graduating seniors, across Alaska; 4) To reach out to students and teachers at Alaska's smaller colleges, health corporations, hospitals, and other organizations at rural sites with the aim of engaging them in INBRE research projects; and 5) To enhance science knowledge of the Alaskan workforce through training programs and transition-to-college offerings at network campuses and Outreach sites. Seven recent UA faculty hires form the intellectual backbone of the research theme, with two new faculty positions proposed in the INBRE. Substantial funds are targeted to provide research project support (pilot project grants) for these young faculty, as well as mentoring, graduate student support, and other faculty training and development opportunities. Bioinformatics Core faculty provide expertise in research approaches and data management to the research core team of investigators. The INBRE Outreach Core program will develop and expand the undergraduate student pipeline into health careers and biomedical graduate education, and includes support for undergraduate research internships, new biomedical course work, and mentoring programs aimed specifically at Alaska Native students.