COBRE: NDS U: BIOPHARMACOLOGY: MS, PROTEASE

COBRE：NDS U：生物药理学：MS、蛋白酶

• 批准号: 7170263
• 负责人: STEFAN BALAZ
• 金额: $ 18.78万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7170263
• 关键词: disease /disorder; endopeptidases; enzyme inhibitors

DESCRIPTION (Adapted from the applicant's abstract): Funds are requested to establish a Center for the investigation of unique strategies to target disease through protease inhibition. A multi-disciplinary approach involving in vitro cellular interactions, synthesis, drug design, targeting-delivery, and biopharmaceutics will be undertaken. The Center will coordinate the expertise of four faculty from Chemistry (Cook, Mallik, Rodgers, and Sibi) and two from Pharmacy (Balaz and Sehgal). The scientific focus of the Center will be the development of therapeutic inhibitors and delivery systems for matrix proteinases, including the family of matrix metalloproteinases (MMPs) and the serine proteases (SPs), urokinase plasminogen activator (uPA) and plasmin. The majority of effort is directed toward the inhibition of MMPs. However, the two serine proteases also play critical roles in matrix homeostasis in both health and disease. A portion of the effort will be directed towards the design and optimization of inhibitors for these enzymes. The effort will consist of four interrelated projects: Project 1, Synthesis; Project 2, Targeting/Delivery; Project 3, Biopharmaceutics/Drug Design; Project 4, in vitro Cellular Interactions (Core). The COBRE Center will build the infrastructure to foster growth of biomedical research in North Dakota. From July 1997 to December 1999 a total of 130 proposals from North Dakota to NIH have been submitted. As of this writing, NDSU has 15 researchers with NIH funded programs. There are on the order of 200 faculty/researchers with biomedically relevant research programs in North Dakota. The disparity between the number of researchers and grant proposal activity represents a potential growth area for the state. The investigators will develop this potential through establishment of the COBRE funded Research Center. The Center will initiate new activities in biomedically relevant areas to address the aforementioned growth areas in a holistic way. These initiatives include: seed grants for North Dakota faculty, establishment of a graduate fellowship program, post-doctoral fellowships, summer research program for undergraduates and faculty from four-year colleges, and NIH workshops. The Center will be vigilant in building and maintaining a favorable environment for fostering new proposals to the NIH at the RO1 level.

描述（改编自申请人的摘要）：资金被要求建立一个中心，用于研究通过蛋白酶抑制靶向疾病的独特策略。 涉及体外细胞相互作用、合成、药物设计、靶向递送和生物药剂学的多学科方法将被采用。 该中心将协调来自化学（库克，马利克，罗杰斯和西比）和两个从药房（巴拉兹和Sehgal）四个教师的专业知识。该中心的科学重点将是开发基质蛋白酶的治疗性抑制剂和递送系统，包括基质金属蛋白酶（MMPs）家族和丝氨酸蛋白酶（SP），尿激酶纤溶酶原激活剂（uPA）和纤溶酶。 大部分的努力是针对抑制MMP。 然而，这两种丝氨酸蛋白酶也在健康和疾病的基质稳态中发挥关键作用。 一部分的努力将针对这些酶的抑制剂的设计和优化。 这项工作将包括四个相互关联的项目：项目1，合成;项目2，靶向/交付;项目3，生物药剂学/药物设计;项目4，体外细胞相互作用（核心）。COBRE中心将建立基础设施，以促进北达科他州生物医学研究的发展。 从1997年7月到1999年12月，北达科他州总共向NIH提交了130份提案。 在撰写本文时，NDSU有15名研究人员参与了NIH资助的项目。 在北达科他州有大约200名教师/研究人员从事生物医学相关的研究项目。 研究人员的数量和拨款申请活动之间的差距代表了该州的一个潜在增长领域。 研究人员将通过建立COBRE资助的研究中心来开发这一潜力。 该中心将在生物医学相关领域发起新活动，以整体方式解决上述增长领域。 这些举措包括：为北达科他州教师提供种子赠款，建立研究生奖学金计划，博士后奖学金，为四年制大学的本科生和教师提供暑期研究计划，以及NIH研讨会。 该中心将保持警惕，在建立和维护一个有利的环境，促进新的建议，在国家卫生研究院的一级。