Klebsiella, phages and the capsule: what's going on?

克雷伯氏菌、噬菌体和胶囊：发生了什么事？

• 批准号: 2869301
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2869301
• 关键词: Klebsiella; phages; capsule; what; going

With the looming antimicrobial resistance crisis, bacteriophages are increasingly investigated as a potential alternative to antibiotics, but the way they mechanisticly interact with bacteria is poorly understood for many systems. This project will focus on the interaction between phages, the Klebsiella capsule and biofilm formation, using transposon-directed insertion sequencing (TraDIS) and advanced biofilm models.In this microbiology project a variety of techniques in molecular microbiology, sequence data analysis and fluorescence microscopy will be used to understand how phage infection drives Klebsiella capsule variation and how that affects virulence and biofilm formation.

随着抗菌素耐药性危机的迫在眉睫，噬菌体作为抗生素的潜在替代品被越来越多地研究，但它们与细菌的机械相互作用方式在许多系统中知之甚少。该项目将利用转座子定向插入测序（TraDIS）和先进的生物膜模型，重点研究噬菌体、克雷伯菌胶囊和生物膜形成之间的相互作用。在这个微生物学项目中，分子微生物学的各种技术，序列数据分析和荧光显微镜将被用来了解噬菌体感染如何驱动克雷伯菌胶囊的变异，以及它如何影响毒力和生物膜的形成。