COBRE: RIH: THEME A: FETAL PROTEINS & PHENOTYPES IN CANCER: NOVEL HCC VACCINES

COBRE：RIH：主题 A：胎儿蛋白质

• 批准号: 7171099
• 负责人: MAUREEN A CHUNG
• 金额: $ 13.62万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171099
• 关键词: clinical research; health science research potential; neoplasm /cancer

DESCRIPTION (provided by applicant): The mission of the Center for Cancer Research Development is to coalesce and foster outstanding, interactive, laboratory-based cancer research centered on the Molecular and Cellular Pathogenesis of Cancer. To this end, three program projects, each with two subprojects will be initiated in year one along with four pilot projects, the latter supported by funds from Rhode Island Hospital/Academic Medical Center (RIH/AMC). The goal will be to develop program projects in four different but related themes, into interactive research groups composed of at least 3 junior investigators supported by peer reviewed grants. This will be accomplished by establishing and perpetuating an intellectually dynamic training environment in which junior investigators will create and disseminate new knowledge and clinical applications and with the guidance of senior faculty mentors, build nationally competitive, independent, but interactive research programs. The investigators will utilize common model systems and state-of-the-art core facilities in administration, career development, proteomics and molecular pathology to 1) discover mechanisms leading to neoplasia and 2) develop clinical applications resulting from this knowledge. The six subprojects, mentored by a team of seven senior faculty including the PI and Co-PI, target programmatic themes in gastrointestinal cancer, developmental proteins and intracellular signaling pathways. A fourth theme in viral mechanisms of carcinogenesis is represented by pilot projects funded by the institution. The proposal represents a strategic partnership in which RIH/AMC will commit significant resources to supplement those requested in this application to build cohesive strength in basic cancer research that complements existing strengths in clinical cancer treatment, outreach, and prevention. The long-term goal of this support is to achieve NCI designation as a Comprehensive Cancer Center. Guidance for the Center will be provided by teams of Internal and External Advisors and Consultants including a Translational Research Group together with a carefully considered plan of training, evaluation and succession. The end result will be a Cancer Research Center of investigators with significant programmatic strengths and translational impact.

描述(申请人提供)：癌症研究发展中心的使命是联合和促进以癌症分子和细胞发病机制为中心的杰出的、互动的、以实验室为基础的癌症研究。为此，将在第一年启动三个方案项目，每个方案项目包括两个子项目，以及四个试点项目，后者由罗德岛医院/学术医学中心(RIH/AMC)提供资金支持。其目标将是开发四个不同但相关主题的方案项目，形成由至少3名初级调查人员组成的互动研究小组，并得到同行审查拨款的支持。 这将通过建立和保持一个充满智力活力的培训环境来实现，在这个环境中，初级调查人员将创造和传播新的知识和临床应用，并在高级教师导师的指导下，建立全国有竞争力的、独立的、但互动的研究计划。研究人员将利用管理、职业发展、蛋白质组学和分子病理学方面的共同模型系统和最先进的核心设施，1)发现导致肿瘤发生的机制，2)根据这一知识开发临床应用。这六个子项目由包括PI和Co-PI在内的七名资深教员组成的团队指导，目标是胃肠道癌症、发育蛋白和细胞内信号通路的程序性主题。病毒致癌机制的第四个主题是由该机构资助的试点项目。该提案代表了RIH/AMC的战略伙伴关系，其中RIH/AMC将投入大量资源来补充本申请中要求的资源，以建立基础癌症研究的凝聚力，补充临床癌症治疗、推广和预防方面的现有优势。这项支持的长期目标是实现NCI被指定为综合癌症中心。中心的指导将由内部和外部顾问和顾问团队提供，其中包括一个翻译研究小组，以及经过仔细考虑的培训、评估和继任计划。最终结果将是一个由研究人员组成的癌症研究中心，具有显著的规划优势和翻译影响。