SD COBRE: MYOCYTE POLARITY AND SIGNAL TRANSDUCTION IN MYOCARDIAL INFARCTION

描述（由申请人提供）：本提案旨在建立一个关于“心血管重塑机制”的生物医学研究卓越中心（COBRE）。心血管疾病占美国所有死亡人数的近一半。近年来，人们已经广泛认识到，心血管系统的病理性重塑可能不仅仅是血液动力学紊乱的结果，而是可能在疾病过程中起主要作用。预防或逆转头部、血管和肾脏重塑的治疗性干预明显降低了死亡率，改善了生活质量。相关的神经体液和分子/信号传导机制知之甚少。认识到这一领域的发现具有巨大的治疗意义，南达科他州大学医学院有意识地努力组建一个研究小组，专注于心血管重塑方面的工作。最近招聘了四名在这一领域有研究兴趣的有前途的新教师。每个人都接受过世界知名调查人员的培训。COBRE主任是国际公认的心血管重塑专家。另外两个NIH资助的心血管专业教师将提供额外的指导和技术援助。累积起来，该小组在生理学，药理学，形态学，分子生物学，信号转导，转基因，基因组学和蛋白质组学方面具有专业知识。COBRE的资助将有助于我们有前途的年轻科学家发展生产力。美国国立卫生研究院资助的研究项目，并将增加深度和额外的专业知识，以集团。我们相信最终的结果将是一个国际公认的研究计划，使该领域的实质性贡献。COBRE包含四个项目和四个核心（包括管理）。项目1由王学军博士领导，将确定泛素-蛋白酶体系统在心力衰竭心脏重塑中的致病作用。由李发谦博士领导的项目2将测试导致心力衰竭室腔扩张的细胞生长中关键信号通路的作用。由Rachid Kacimi博士领导的项目3将研究新发现的细胞因子在缺血性心力衰竭中的作用。

DESCRIPTION (provided by applicant): This proposal is to establish a Center of Biomedical Research Excellence; (COBRE) on "Mechanisms of Cardiovascular Remodeling". Cardiovascular diseases account for nearly half of all deaths in the US. In recent years, it has become widely recognized that pathological remodeling of the cardiovascular system may not be simply a consequence of hemodynamic derangements but may play a primary role in the disease process. Therapeutic interventions that prevent or reverse remodeling in the head, blood vessels, and kidneys clearly lead to a reduction in mortality and improvement in quality of life. The associated neurohumoral and molecular/signaling mechanisms are poor y understood. Realizing the enormous therapeutic implications of discoveries in this field, the University of South Dakota School of Medicine has made a conscious effort to assemble a team of investigators to focus on work in cardiovascular remodeling. Four promising new faculty with research interests in this area have been recruited recently. Each have trained with world-renowned investigators. The COBRE Director is an internationally recognized expert in cardiovascular remodeling. Two other NIH funded faculty with cardiovascular expertise will provide additional mentoring and technical assistance. Cumulatively, the group has expertise in physiology, pharmacology, morphology, molecular biology, signal transduction, transgenesis, genomics, and proteomics. COBRE funding will facilitate our promising junior scientists in developing productive. NIH-funded research programs and will add depth and additional expertise to the croup. We believe the end result will be an internationally recognized research program that makes substantial contributions to the field. The COBRE contains four projects and four cores (including administration). Project 1, led by Dr. Xuejun Wang, will define the pathogenic role of the ubiquitin-proteasome system in cardiac remodeling in failure. Project 2, led by Dr. Faqian Li, will test the role of a key signaling pathway in cell growth leading to chamber dilatation in heart failure. Project 3, led by Dr. Rachid Kacimi, will examine the role of newly discovered cytokines in ischemic heart failure.