MT COBRE: EFFECT OF METAL MIXTURES ON GENE EXPRESSION & CARCINOGENESIS

MT COBRE：金属混合物对基因表达的影响

• 批准号: 7171055
• 负责人: Mark A Pershouse
• 金额: $ 15.57万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171055
• 关键词: clinical research; environmental health; health science research potential; health science research support

DESCRIPTION (provided by applicant): The CEHS was established in 2000 with the goal of developing a nationally competitive research program to study the mechanism of human disease and environmental impacts on human disease. In order to achieve this goal three focus areas of research were selected in order to facilitate the development of a critical mass of investigators in each area and on the basis of national need and expertise within the existing faculty. These focus areas are respiratory/immunotoxicology, neurotoxicology, and genetic and cardiovascular toxicology. With the aid of startup support five talented new faculty were hired and a sixth is being recruited. State-of-the-art core facilities were established and a strong mentoring program was put into place. This COBRE application is an ideal fit to develop the new faculty, hire additional faculty to further enhance the existing faculty and to enhance the support network and the infrastructure to develop the CEHS to a nationally competitive center. The specific aims of this application are: Aim 1 Promote the development of six talented faculty through the support of individual sub-projects Aim 2 Enhance the critical mass of competitive CEHS investigators at the UM through strategic recruitment of four new faculty. Aim 3 Establish a support network for CEHS investigators that promotes infrastructure development, collaborative interaction and facilitate mentoring. Aim 4 Enhance the infrastructure for CEHS research through the acquisition of critically needed instrumentation for a shared ICPMS and Flow Cytometer; and improve facilities, i.e., clean room for ICPMS, tissue culture, small animal surgery and a bioinformatics and computational core facility. We propose that with the achievement of these specific aims that all of the investigators supported by this COBRE grant will move into R01 funding and that the an overall research environment will have been created so that the CEHS investigators will be able to obtain a NIEHS center grant, a Ph.D. training grant from the NIEHS and program project grant support.

CEHS成立于2000年，目标是开发一个具有国家竞争力的研究计划，以研究人类疾病的机制和环境对人类疾病的影响。为了实现这一目标，选择了三个重点研究领域，以促进每个领域的调查人员的临界质量的发展，并根据国家的需要和现有教师的专业知识。这些重点领域是呼吸/免疫毒理学、神经毒理学以及遗传和心血管毒理学。在创业支持的帮助下，聘请了五名有才华的新教师，第六名正在招聘中。建立了最先进的核心设施，并实施了强有力的指导方案。这个COBRE应用程序是一个理想的适合发展新的教师，雇用额外的教师，以进一步提高现有的教师，并加强支持网络和基础设施，以发展CEHS的国家竞争力的中心。 本申请的具体目的是： 目标1通过支持各个子项目，促进六个优秀教师的发展 目标2通过战略招聘四名新教师，提高竞争力的CEHS调查人员在UM的临界质量。 目标3为CEHS调查人员建立一个支持网络，促进基础设施的发展，合作互动和促进指导。 目标4：通过为共用的ICPMS和流式细胞仪购置急需的仪器，加强CEHS研究的基础设施;并改善设施，洁净室用于ICPMS、组织培养、小动物手术和生物信息学和计算核心设施。 我们建议，随着这些具体目标的实现，所有由COBRE赠款支持的研究人员将进入R 01资金，并将创造一个整体的研究环境，以便CEHS研究人员能够获得NIEHS中心赠款，博士学位。来自NIEHS的培训补助金和计划项目补助金支持。